Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia.
Sci Rep. 2024 Jun 1;14(1):12620. doi: 10.1038/s41598-024-63389-x.
Ivermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle. Nevertheless, IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls. The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment. Laboratory-reared, insecticide-susceptible Kisumu Anopheles gambiae were exposed to IVM on impregnated netting materials and sprayed plastered- and mud walls using cone bioassays. The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM. The effect was slower on the IVM-sprayed walls compared to the treated nettings. Further work to evaluate possibility of IVM as a new insecticide formulation in LLINs and IRS will be required.
伊维菌素 (IVM) 被提议作为一种新的疟疾控制工具，因为它对吸食经处理的人类或牛的病媒具有毒性。然而，当 IVM 应用于蚊帐或喷涂墙壁时，它可能具有直接的杀蚊效果。本概念验证研究在实验室和半野外环境中测试了 IVM 作为长效杀虫剂（LLIN）和室内滞留喷洒（IRS）的新型杀虫剂的应用潜力。使用锥形生物测定法，将实验室饲养的、对杀虫剂敏感的基苏木冈比亚按蚊暴露于浸渍在网眼材料中的 IVM 上，并暴露于喷涂灰泥和泥墙。结果表明，IVM 对这种蚊子菌株具有直接的杀蚊作用，因为所有蚊子在接触 IVM 后 24 小时内死亡。与处理过的网眼相比，IVM 喷涂墙壁的效果较慢。需要进一步研究以评估 IVM 作为 LLIN 和 IRS 中新型杀虫剂配方的可能性。
