Division of Internal Medicine for the Aged, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
Division of Geriatrics, Hospital of Valais, Martigny, Switzerland.
J Am Med Dir Assoc. 2024 Aug;25(8):105047. doi: 10.1016/j.jamda.2024.105047. Epub 2024 May 31.
This report aimed to describe mortality at 18 months in older survivors of the first wave of COVID-19.
Observational cohort study.
Patients aged ≥65 years hospitalized for COVID-19 in the acute geriatric wards of 2 centers.
Characteristics of deceased and survivors were compared by Fisher exact, Mann-Whitney U, or 2-tailed t tests. Survival rates were analysed by Cox proportional hazards regression models.
Of a total of 323 patients admitted during the first wave, 196 survived the acute phase, with 34 patients who died in the 18 months after hospital discharge (17.3%). Higher mortality was observed in patients living in nursing homes (P = .033) and in those who were hospitalized after discharge during the follow-up period (97.1% vs 72.8%, P = .001). There was no difference in survival curves according to age, sex, presence of dyspnea, and dementia. Living in a nursing home significantly increased the mortality rates in the multivariate model adjusted for age and sex (hazard ratio 3.07, 95% CI 1.47-6.40; P = .007).
No excess mortality was observed during 18 months in older survivors of COVID-19. Living in a nursing home was associated with decreased survival rates.
本报告旨在描述 COVID-19 第一波疫情中年龄较大幸存者的 18 个月死亡率。
观察性队列研究。
在 2 个中心的急性老年病房住院治疗 COVID-19 的年龄≥65 岁的患者。
通过 Fisher 精确检验、Mann-Whitney U 检验或双尾 t 检验比较死亡和幸存者的特征。通过 Cox 比例风险回归模型分析生存率。
在第一波疫情期间，共收治 323 例患者，其中 196 例在急性期存活，出院后 18 个月内死亡 34 例（17.3%）。在疗养院居住的患者（P =.033）和在随访期间出院后住院的患者（97.1% vs 72.8%，P =.001）死亡率更高。根据年龄、性别、呼吸困难和痴呆的存在，生存曲线没有差异。在调整年龄和性别后，住在疗养院显著增加了多变量模型中的死亡率（危险比 3.07，95%CI 1.47-6.40；P =.007）。
在 COVID-19 幸存者的 18 个月内没有观察到额外的死亡率。住在疗养院与生存率下降有关。
