Department of Physical Medicine and Rehabilitation, Physical Medicine and Rehabilitation Hospital, Kuwait.
J Musculoskelet Neuronal Interact. 2024 Jun 1;24(2):228-231.
Increasingly Charcot neuroarthropathy (CN) is being recognized in patients with Charcot-Marie-Tooth (CMT) disease. In this report, we describe a case of CN in a CMT patient, adding to the very scarce literature describing this association. We additionally report his unique evaluation with fluorodeoxyglucose (FDG) and sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) scanning, the study of which is limited in CN despite its promising role. A 54-year-old known case of CMT, presented with left foot pain, and swelling for 4 months. Weakness and sensory deficits as a result of CMT were evident in both lower and upper limbs. His x-ray was suggestive of CN. Both FDG and NaF PET/CT scanning demonstrated increased tracer uptake in the first tarsometatarsal joint (TMTJ), in keeping with CN. Recognition of the association of CMT with CN is of vital importance as early diagnosis relies on high clinical suspicion. Characterizing risk factors of CN in CMT patients is still under study. Moreover, there is lack of data evaluating the role of PET/CT in CN and specifically in the context of CMT.
Charcot 神经关节病（CN）在遗传性运动感觉神经病（CMT）患者中越来越被认识。本报告描述了一例 CMT 患者的 CN 病例，增加了非常有限的描述这种关联的文献。我们还报告了他用氟脱氧葡萄糖（FDG）和氟化钠（NaF）正电子发射断层扫描/计算机断层扫描（PET/CT）进行的独特评估，尽管该研究在 CN 中具有很大的潜力，但在 CN 中该研究是有限的。一名 54 岁的 CMT 已知病例，表现为左脚疼痛和肿胀 4 个月。四肢均有 CMT 导致的无力和感觉缺失。他的 X 光片提示 CN。FDG 和 NaF PET/CT 扫描均显示第一跖跗关节（TMTJ）的示踪剂摄取增加，与 CN 一致。认识到 CMT 与 CN 的关联非常重要，因为早期诊断依赖于高度的临床怀疑。CMT 患者的 CN 危险因素的特征仍在研究中。此外，缺乏数据评估 PET/CT 在 CN 中的作用，特别是在 CMT 中的作用。
