Shaw D D, Potts D G
Invest Radiol. 1985 Jan-Feb;20(1 Suppl):S10-3. doi: 10.1097/00004424-198501002-00004.
This review summarizes the biological profile of the nonionic contrast medium, iohexol, with particular emphasis on neurovascular and myelographic applications. Iohexol was compared with conventional ionic media and with newer nonionic agents in a variety of animal models. Studies of systemic toxicity (teratogenicity, mutagenicity, and embryotoxicity effects) and cerebrovascular effects (epileptogenicity and arachnoiditis potential) are reported. Results indicate that iohexol has a lower toxicity than ionic and other nonionic contrast media.
本综述总结了非离子型造影剂碘海醇的生物学特性，尤其着重于神经血管造影和脊髓造影应用。在多种动物模型中，将碘海醇与传统离子型造影剂以及新型非离子型造影剂进行了比较。报告了关于全身毒性（致畸性、致突变性和胚胎毒性作用）和脑血管作用（致癫痫性和蛛网膜炎可能性）的研究。结果表明，碘海醇的毒性低于离子型造影剂和其他非离子型造影剂。
