早发型与晚发型遗忘型阿尔茨海默病的内侧颞叶萎缩模式
Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease.
作者信息
Wuestefeld Anika, Binette Alexa Pichet, van Westen Danielle, Strandberg Olof, Stomrud Erik, Mattsson-Carlgren Niklas, Janelidze Shorena, Smith Ruben, Palmqvist Sebastian, Baumeister Hannah, Berron David, Yushkevich Paul A, Hansson Oskar, Spotorno Nicola, Wisse Laura Em
机构信息
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, 22242 Lund, Sweden.
Department of Diagnostic Radiology, Clinical Sciences, Lund University, 22242 Lund, Sweden.
出版信息
bioRxiv. 2024 May 21:2024.05.21.594976. doi: 10.1101/2024.05.21.594976.
BACKGROUND
The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.
METHODS
BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison, late-onset AD (LOAD, ≥70 years, n=154) and Aβ-negative cognitively unimpaired controls were included. MTL subregions and biomarkers of (co-)pathologies were measured.
RESULTS
AD groups showed smaller MTL subregions compared to controls. Atrophy patterns were similar across AD groups, although LOAD showed thinner entorhinal cortices compared to EOAD. EOAD showed lower WMH compared to LOAD. No differences in MTL tau-PET or transactive response DNA binding protein 43-proxy positivity was found.
CONCLUSIONS
We found in vivo evidence for MTL atrophy in amnestic EOAD and overall similar levels to LOAD of MTL tau pathology and co-pathologies.
背景
内侧颞叶（MTL）被认为在早发性阿尔茨海默病（EOAD）中相对未受影响。然而，目前缺乏对遗忘型EOAD中MTL亚区体积及萎缩驱动因素的详细研究。
方法
纳入BioFINDER-2研究中存在记忆障碍、淀粉样蛋白-β状态异常及tau正电子发射断层扫描（PET）异常的参与者。其中包括41名年龄≤65岁的EOAD个体，作为对照，还纳入了晚发性阿尔茨海默病（LOAD，≥70岁，n = 154）个体以及淀粉样蛋白-β阴性认知功能未受损的对照组。对MTL亚区及（共）病理学生物标志物进行测量。
结果
与对照组相比，阿尔茨海默病组的MTL亚区较小。尽管与EOAD相比，LOAD的内嗅皮质更薄，但两组阿尔茨海默病的萎缩模式相似。与LOAD相比，EOAD的白质高信号较低。未发现MTL tau-PET或反应性DNA结合蛋白43替代物阳性方面的差异。
结论
我们发现了遗忘型EOAD中MTL萎缩的体内证据，且MTL tau病理及共病理学水平总体上与LOAD相似。
Zotero 插件