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前列腺支架:当前证据的叙述性综述

Prostatic stents: a narrative review of current evidence.

作者信息

Cerrato Clara, Antoniou Vaki, Napolean Fernandes Shriya, Madaan Sanjeev, Somani Bhaskar Kumar

机构信息

University Hospital Southampton NHS Trust, Southampton, UK.

Darent Valley Hospital (DVH), Dartford, UK.

出版信息

Ther Adv Urol. 2024 May 30;16:17562872241255262. doi: 10.1177/17562872241255262. eCollection 2024 Jan-Dec.

Abstract

Benign prostatic hyperplasia (BPH) is a common chronic urologic condition affecting approximately 50% of men above the age of 60. As per European Association of Urology Guidelines, BPH can be treated according to a stepwise approach starting from a conservative management, a pharmacologic approach, and finally surgery. Both medical and surgical therapies have side effects, impacting on ejaculation and sexual function and patients with multiple comorbidities might not be considered surgically suitable candidates. Prostatic stents offer a minimally invasive procedures in an out-patient setting, possibly under local anaesthesia. Utilized since the 1980s, the past stents encompassed permanent (epithelializing) or temporary (non-epithelializing) devices, like the Uro-Lume (American Medical Systems, Minnetonka, MN, USA) and the Memokath, or Memotherm (Engineers & Doctors A/S, Denmark), and the biodegradable stents made of self-reinforced poly-L-lactide or braided poly lactic-co-glycolic acid. Previous stents however showed a quite high rate of complications among which pain, incontinence, infections, stent migration or blockage, and incomplete degradation that might lead to premature removal of stent. The stents currently available on the market instead are the temporary device Allium Triangular Prostatic Urethral Stent (Allium Urological Solutions, Caesarea, Israel) and the temporary stent SPANNER (AbbeyMoor Medical, Inc., Parkers Prairie, MN, USA), which might be used in case of bladder outflow obstruction, post-operatively, or for acute urinary retention. Studies showed encouraging results, in terms of effectiveness and safety improving patients' quality of life and International Prostate Symptom Score, but longer-term studies are needed to identify the most suitable patients who might benefit from their use. Newer stents and nitinol devices are currently investigated, and we are waiting for the results of the ongoing clinical trials.

摘要

良性前列腺增生(BPH)是一种常见的慢性泌尿系统疾病,影响着约50%的60岁以上男性。根据欧洲泌尿外科学会指南,BPH可根据从保守治疗、药物治疗到最终手术的逐步方法进行治疗。药物治疗和手术治疗都有副作用,会影响射精和性功能,患有多种合并症的患者可能不被认为是手术的合适候选人。前列腺支架在门诊环境中提供一种微创手术,可能在局部麻醉下进行。自20世纪80年代以来开始使用,过去的支架包括永久性(上皮化)或临时性(非上皮化)装置,如Uro-Lume(美国美敦力公司,明尼通卡,明尼苏达州,美国)和Memokath或Memotherm(丹麦工程师与医生公司),以及由自增强聚-L-丙交酯或编织聚乳酸-乙醇酸制成的可生物降解支架。然而,以前的支架显示出相当高的并发症发生率,其中包括疼痛、尿失禁、感染、支架迁移或堵塞以及不完全降解,这可能导致支架过早取出。目前市场上可用的支架是临时性装置葱形三角前列腺尿道支架(以色列凯撒利亚葱形泌尿解决方案公司)和临时性支架SPANNER(美国明尼苏达州帕克尔斯普瑞艾比摩尔医疗公司),可用于膀胱流出道梗阻、术后或急性尿潴留的情况。研究显示了令人鼓舞的结果,在有效性和安全性方面改善了患者的生活质量和国际前列腺症状评分,但需要进行长期研究以确定可能从其使用中受益的最合适患者。目前正在研究更新的支架和镍钛诺装置,我们正在等待正在进行的临床试验结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/926e/11143863/08a854f4e527/10.1177_17562872241255262-fig1.jpg

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