Patterson Rachel A, Brooks Heather, Mirjalili Mina, Rashidi-Ranjbar Neda, Zomorrodi Reza, Blumberger Daniel M, Fischer Corinne E, Flint Alastair J, Graff-Guerrero Ariel, Herrmann Nathan, Kennedy James L, Kumar Sanjeev, Lanctôt Krista L, Mah Linda, Mulsant Benoit H, Pollock Bruce G, Voineskos Aristotle N, Wang Wei, Rajji Tarek K
Centre for Addiction and Mental Health, Toronto, ON M6J 1H4 Canada.
Department of Psychiatry, TemertyFaculty of Medicine, University of Toronto, Toronto, ON M5S 1A1 Canada.
Cogn Neurodyn. 2024 Jun;18(3):795-811. doi: 10.1007/s11571-023-09938-y. Epub 2023 Mar 4.
Theta-gamma coupling (TGC) is a neurophysiological process that supports working memory. Working memory is associated with other clinical and biological features. The extent to which TGC is associated with these other features and whether it contributes to working memory beyond these features is unknown. Two-hundred-and-three older participants at risk for Alzheimer's dementia-98 with mild cognitive impairment (MCI), 39 with major depressive disorder (MDD) in remission, and 66 with MCI and MDD (MCI + MDD)-completed a clinical assessment, N-back-EEG, and brain MRI. Among them, 190 completed genetic testing, and 121 completed [C] Pittsburgh Compound B ([11C] PIB) PET imaging. Hierarchical linear regressions were used to assess whether TGC is associated with demographic and clinical variables; Alzheimer's disease-related features ( ε4 carrier status and β-amyloid load); and structural features related to working memory. Then, linear regressions were used to assess whether TGC is associated with 2-back performance after accounting for these features. Other than age, TGC was not associated with any non-neurophysiological features. In contrast, TGC (β = 0.27; = 0.006), age (β = - 0.29; = 0.012), and parietal cortical thickness (β = 0.24; = 0.020) were associated with 2-back performance. We also examined two other EEG features that are linked to working memory-theta event-related synchronization and alpha event-related desynchronization-and found them not to be associated with any feature or performance after accounting for TGC. Our findings suggest that TGC is a process that is independent of other clinical, genetic, neurochemical, and structural variables, and supports working memory in older adults at risk for dementia.
The online version contains supplementary material available at 10.1007/s11571-023-09938-y.
θ-γ耦合（TGC）是一种支持工作记忆的神经生理过程。工作记忆与其他临床和生物学特征相关。TGC与这些其他特征相关的程度以及它是否在这些特征之外对工作记忆有贡献尚不清楚。203名有患阿尔茨海默病痴呆风险的老年参与者——98名患有轻度认知障碍（MCI），39名缓解期重度抑郁症（MDD）患者，66名患有MCI和MDD（MCI + MDD）——完成了临床评估、N-back脑电图和脑部磁共振成像。其中，190名完成了基因检测，121名完成了[碳-11]匹兹堡化合物B（[11C] PIB）正电子发射断层显像。采用分层线性回归来评估TGC是否与人口统计学和临床变量、阿尔茨海默病相关特征（ε4携带者状态和β-淀粉样蛋白负荷）以及与工作记忆相关的结构特征相关。然后，在考虑这些特征后，采用线性回归来评估TGC是否与2-back表现相关。除年龄外，TGC与任何非神经生理特征均无关联。相比之下，TGC（β = 0.27；P = 0.006）、年龄（β = -0.29；P = 0.012）和顶叶皮质厚度（β = 0.24；P = 0.020）与2-back表现相关。我们还研究了与工作记忆相关的另外两个脑电图特征——θ事件相关同步化和α事件相关去同步化——发现在考虑TGC后，它们与任何特征或表现均无关联。我们的研究结果表明，TGC是一个独立于其他临床、遗传、神经化学和结构变量的过程，并支持有痴呆风险的老年人的工作记忆。
在线版本包含可在10.1007/s11571-023-09938-y获取的补充材料。
