Boudabbous Mona, Barkia Baha, Feki Wiem, Gdoura Héla, Chtourou Lassad, Moalla Manel, Mnif Leila, Amouri Ali, Mnif Zeinab, Tahri Nabil
Gastroenterology Department, Hédi Chaker Hospital, Sfax, 3000, Tunisia.
Medecin Sfax University, Sfax university, 3000, Tunisia.
Future Sci OA. 2024 May 15;10(1):FSO907. doi: 10.2144/fsoa-2023-0109. eCollection 2024.
Non-melanoma skin cancers are more common in people with inflammatory bowel disease. However, these tumors can rarely mimic a cutaneous manifestation of the disease, which delays diagnosis and clouds prognosis. A 35-year-old man with stenosing and fistulizing ileocolic Crohn's disease developed squamous cell carcinoma mimicking a groin fold abscess. After surgical drainage of the abscess, despite antibiotics and therapy combining azathioprine with infliximab, the abscess has recurred. Biopsies revealed a cutaneous squamous cell carcinoma. Palliative radiotherapy-chemotherapy was initiated, but the patient died after 3 months. This observation illustrates the increased risk of non-melanoma skin cancers in inflammatory bowel disease patients, particularly those exposed to thiopurines, and the value of diagnosing them at an early stage.
非黑色素瘤皮肤癌在炎症性肠病患者中更为常见。然而，这些肿瘤很少能模仿该疾病的皮肤表现，从而延误诊断并使预后不明。一名患有狭窄性和瘘管性回结肠克罗恩病的35岁男性发生了模仿腹股沟褶皱脓肿的鳞状细胞癌。脓肿手术引流后，尽管使用了抗生素以及硫唑嘌呤与英夫利昔单抗联合治疗，脓肿仍复发。活检显示为皮肤鳞状细胞癌。开始了姑息性放化疗，但患者在3个月后死亡。这一观察结果说明了炎症性肠病患者，尤其是那些使用硫嘌呤类药物的患者发生非黑色素瘤皮肤癌的风险增加，以及早期诊断它们的价值。
