Department of Pharmacy, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman.
Department of Medicine, Sultan Qaboos University Hospital, Sultan Qaboos University, Muscat, Oman.
Sultan Qaboos Univ Med J. 2024 May;24(2):216-220. doi: 10.18295/squmj.1.2024.003. Epub 2024 May 27.
This study aimed to report any suspected adverse drug reactions (ADRs) experienced by all vaccinated staff and students in a tertiary teaching hospital following COVID-19 vaccination.
This retrospective study was conducted during the COVID-19 vaccination campaign at Sultan Qaboos University and Hospital in Muscat, Oman, from August to September 2021. An online survey was generated and sent to all staff and students via email and text messages. An announcement was made on the hospital website with a link to the survey.
A total of 8,421 individuals reported being vaccinated at least once with a total of 11,468 doses administered from January to July 2021; 8,014 staff and students received the Pfizer-Biotech vaccine while 3,454 staff and students received the Oxford-AstraZeneca vaccine. The survey received a total of 3,275 responses (response rate = 38.8%). Of these, 741 individuals (22.6%) experienced an ADR after vaccination and 67.2% (n = 498) were females ( <0.001). The majority of the ADRs reported were fever and chills (19.7%) followed by localised pain and swelling at the injection site (18.8%). Other ADRs such as hair loss (0.5%) were reported, and one staff/student reported a clot in the right leg. Among the responders, 27.0% considered their ADRs as mild while 25.0% considered them as severe.
In the study cohort, mild symptoms of COVID-19 vaccines were reported. Females experienced more ADRs compared to males. Long-term observation of ADRs to the vaccines and follow-up monitoring should be done on subjects to preclude any unwanted effects.
本研究旨在报告在 COVID-19 疫苗接种后，一家三级教学医院所有接种疫苗的员工和学生所经历的任何疑似药物不良反应（ADR）。
本回顾性研究于 2021 年 8 月至 9 月在阿曼马斯喀特的苏丹卡布斯大学医院进行。通过电子邮件和短信向所有员工和学生发送了一份在线调查。医院网站上发布了一则公告，其中包含调查链接。
共有 8421 人报告至少接种过一次疫苗，共接种了 11468 剂，接种时间为 2021 年 1 月至 7 月；8014 名员工和学生接种了辉瑞-生物技术疫苗，3454 名员工和学生接种了牛津-阿斯利康疫苗。调查共收到 3275 份回复（回复率=38.8%）。其中，741 人（22.6%）在接种疫苗后出现不良反应，67.2%（n=498）为女性（<0.001）。报告的大多数不良反应为发热和寒战（19.7%），其次为注射部位局部疼痛和肿胀（18.8%）。其他不良反应如脱发（0.5%）也有报告，一名员工/学生报告右腿有血栓。在应答者中，27.0%认为他们的不良反应为轻度，25.0%认为为重度。
在研究队列中，报告了 COVID-19 疫苗的轻度症状。女性比男性经历更多的不良反应。应对接种者的疫苗不良反应进行长期观察和随访监测，以排除任何不良影响。
