Um Young Woo, Park Inwon, Lee Jae Hyuk, Kim Hee Eun, Han Dongkwan, Kang Seung Hyun, Kim Seonghye, Jo You Hwan
Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea.
Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea.
Infect Drug Resist. 2024 May 28;17:2141-2147. doi: 10.2147/IDR.S464286. eCollection 2024.
Proper antibiotic administration is crucial for sepsis management. Given the escalating incidence of antimicrobial resistance, there is a pressing need for indicators of antimicrobial susceptibility with short turnaround times. This study aimed to investigate the potential of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as an early biomarker for in vivo antibiotic susceptibility in patients with sepsis.
We conducted a retrospective analysis of plasma samples from patients enrolled in a pre-established study designed to investigate prognostic biomarkers in patients with sepsis or septic shock. Baseline and 6 h sTREM-1 levels were examined using enzyme-linked immunosorbent assays. The primary outcome of the study was the comparison of percentage changes in sTREM-1 levels at the 6 h relative to baseline with respect to antibiotic susceptibility.
Of the 596 patients enrolled in the pre-established study, 29 with a median age of 75.8 and a 28-day mortality rate of 17.2% were included in the present analysis. Among these patients, 24 were classified into the susceptible group, whereas the remaining five were classified into the resistant group. The trend in plasma sTREM-1 levels differed with respect to antibiotic susceptibility. Moreover, percentage change in sTREM-1 levels at the 6 h relative to baseline was significantly higher in the resistant group ( = 0.028).
The trend in plasma sTREM-1 levels in patients with sepsis differed with respect to antibiotic susceptibility, with a higher percentage change in patients treated with inappropriate antibiotics. These findings indicate the potential utility of sTREM-1 as an early biomarker of antibiotic susceptibility.
恰当使用抗生素对于脓毒症的治疗至关重要。鉴于抗菌药物耐药性的不断增加，迫切需要周转时间短的抗菌药物敏感性指标。本研究旨在探讨髓系细胞触发受体-1（sTREM-1）作为脓毒症患者体内抗生素敏感性早期生物标志物的潜力。
我们对参与一项既定研究的患者血浆样本进行了回顾性分析，该研究旨在调查脓毒症或脓毒性休克患者的预后生物标志物。使用酶联免疫吸附测定法检测基线和6小时时的sTREM-1水平。本研究的主要结果是比较6小时时sTREM-1水平相对于基线的百分比变化与抗生素敏感性之间的关系。
在既定研究纳入的596例患者中，本分析纳入了29例患者，中位年龄为75.8岁，28天死亡率为17.2%。在这些患者中，24例被归类为敏感组，其余5例被归类为耐药组。血浆sTREM-1水平的趋势因抗生素敏感性而异。此外，耐药组中6小时时sTREM-1水平相对于基线的百分比变化显著更高（P = 0.028）。
脓毒症患者血浆sTREM-1水平的趋势因抗生素敏感性而异，使用不恰当抗生素治疗的患者百分比变化更高。这些发现表明sTREM-1作为抗生素敏感性早期生物标志物的潜在效用。
