Pethő Ákos Géza, Tapolyai Mihály, Csongrádi Éva, Orosz Petronella
Faculty of Medicine, Semmelweis University, Department of Internal Medicine and Oncology, Budapest, Hungary.
Medicine Service, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
J Clin Transl Endocrinol. 2024 May 22;36:100354. doi: 10.1016/j.jcte.2024.100354. eCollection 2024 Jun.
Chronic kidney disease (CKD) is a progressive and incurable condition that imposes a significant burden on an aging society. Although the exact prevalence of this disease is unknown, it is estimated to affect at least 800 million people worldwide. Patients with diabetes or hypertension are at a higher risk of developing chronic kidney damage. As the kidneys play a crucial role in vital physiological processes, damage to these organs can disrupt the balance of water and electrolytes, regulation of blood pressure, elimination of toxins, and metabolism of vitamin D. Early diagnosis is paramount to prevent potential complications. Treatment options such as dietary modifications and medications can help slow disease progression. In our narrative review, we have summarized the available therapeutic options to slow the progression of chronic kidney disease. Many new drug treatments have recently become available, offering a beacon of hope and optimism in CKD management. Nonetheless, disease prevention remains the most critical step in disease management. Given the significant impact of CKD on public health, there is a pressing need for further research. With the development of new technologies and advancements in medical knowledge, we hope to find more effective diagnostic tools and treatments for CKD patients.
慢性肾脏病（CKD）是一种渐进性且无法治愈的疾病，给老龄化社会带来了沉重负担。尽管这种疾病的确切患病率尚不清楚，但据估计全球至少有8亿人受其影响。糖尿病或高血压患者发生慢性肾脏损害的风险更高。由于肾脏在重要生理过程中起着关键作用，这些器官受损会扰乱水和电解质平衡、血压调节、毒素清除以及维生素D的代谢。早期诊断对于预防潜在并发症至关重要。饮食调整和药物等治疗选择有助于减缓疾病进展。在我们的叙述性综述中，我们总结了现有的减缓慢性肾脏病进展的治疗选择。最近有许多新的药物治疗可供使用，为慢性肾脏病的管理带来了希望和乐观的曙光。尽管如此，疾病预防仍然是疾病管理中最关键的一步。鉴于慢性肾脏病对公众健康的重大影响，迫切需要进一步研究。随着新技术的发展和医学知识的进步，我们希望能为慢性肾脏病患者找到更有效的诊断工具和治疗方法。
