阿尔茨海默病与周围性前庭障碍的关联：一项病例对照研究。

Association of Alzheimer's Disease With Peripheral Vestibular Disorder: A Case-Control Study.

机构信息

Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan.

Department of Otolaryngology, Wan Fang Hospital, Taipei, Taiwan.

出版信息

Laryngoscope. 2024 Nov;134(11):4730-4735. doi: 10.1002/lary.31558. Epub 2024 Jun 3.

DOI:10.1002/lary.31558

PMID:38828678

Abstract

OBJECTIVES

Vestibular disorders can impact cognitive domains, including spatial orientation and memory, which are also affected in Alzheimer's disease. This study aimed to examine the association between Alzheimer's disease and a prior diagnosis of peripheral vestibular disorders in the elderly Taiwanese population.

METHODS

The case-control study sample was retrieved from Taiwan's Longitudinal Health Insurance Database 2010. We included 3138 cases with Alzheimer's disease and 9414 propensity-matched controls. We conducted multivariable logistic regression modeling to investigate the association between Alzheimer's disease and a prior diagnosis of peripheral vestibular disorders after accounting for sociodemographic characteristics and medical comorbidities including diabetes, coronary heart disease, hypertension, hyperlipidemia, and hearing loss.

RESULTS

The results revealed a statistically significant difference in the prevalence of prior peripheral vestibular disorders between patients with Alzheimer's disease and controls; 20.6% among patients with Alzheimer's disease and 11.4% among controls (p < 0.001). Multivariable logistic regression analysis found that patients with Alzheimer's disease were twice as likely as controls to have had a prior diagnosis of peripheral vestibular disorders, adjusted odds ratio 2.040 (95% confidence interval: 1.829-2.274).

CONCLUSIONS

The findings suggest the possibility of shared or related pathophysiological pathways in Alzheimer's disease and vestibular dysfunction disorders.

LEVEL OF EVIDENCE

3 Laryngoscope, 134:4730-4735, 2024.

摘要

目的

前庭障碍可影响认知领域，包括空间定向和记忆，而这些认知领域在阿尔茨海默病中也受到影响。本研究旨在探讨老年人中阿尔茨海默病与外周前庭障碍既往诊断之间的关联。

方法

本病例对照研究的样本来自台湾 2010 年纵向健康保险数据库。我们纳入了 3138 例阿尔茨海默病患者和 9414 例倾向评分匹配的对照者。我们进行了多变量逻辑回归模型分析，以调查在考虑到社会人口统计学特征和包括糖尿病、冠心病、高血压、高血脂和听力损失在内的共病后，阿尔茨海默病与外周前庭障碍既往诊断之间的关联。

结果

结果显示，阿尔茨海默病患者与对照组之间外周前庭障碍既往诊断的患病率存在统计学显著差异；阿尔茨海默病患者中为 20.6%，对照组中为 11.4%（p<0.001）。多变量逻辑回归分析发现，阿尔茨海默病患者发生外周前庭障碍既往诊断的可能性是对照组的两倍，调整后的优势比为 2.040（95%置信区间：1.829-2.274）。