Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Aliment Pharmacol Ther. 2024 Aug;60(3):378-388. doi: 10.1111/apt.18101. Epub 2024 Jun 3.
The objective of the study was to analyse the prevalence, incidence, and death of alcohol-associated liver disease (ALD) among adolescents and young adults globally, continentally, and nationally, focusing on trends over time.
The study analysed data from the Global Burden of Disease (GBD) study between 2000 and 2019. It examined ALD's prevalence, incidence, and death in adolescents and young adults aged 15-29, segmented by region, nation, and sociodemographic index. The analysis utilised Joinpoint regression modelling to calculate the annual per cent change (APC) in the rate of these parameters over time.
In 2019, there were 281,450 ALD prevalences, 18,930 incidences, and 3190 deaths among adolescents and young adults globally. From 2000 to 2019, the age-adjusted prevalence rate per 100,000 increased in the 25-29 age group (APC: +0.6%, p = 0.003), remained stable among ages 20-24 (p = 0.302) and ages 15-19 (p = 0.160). Prevalence increased significantly from age 15-19 to 20-24 (19-fold increase) and from age 20-24 to 25-29 (2.5-fold increase). ALD prevalence rates increased in all age groups in adolescents and young adults in Africa and the Eastern Mediterranean region. Around three-quarters of countries and territories experienced an increase in ALD incidence rates in young adults.
Over two decades, the burden of ALD among adolescents and young adults has increased globally. The study emphasises the importance of public health policies aimed at reducing alcohol consumption and preventing ALD among younger populations.
本研究旨在分析全球、各大洲和各国青少年和年轻人中与酒精相关的肝病（ALD）的流行率、发病率和死亡率，重点关注随时间推移的趋势。
本研究分析了 2000 年至 2019 年全球疾病负担（GBD）研究的数据。研究分析了年龄在 15-29 岁的青少年和年轻人中 ALD 的流行率、发病率和死亡率，按地区、国家和社会人口指数进行细分。分析采用 Joinpoint 回归模型计算这些参数随时间的年度百分比变化（APC）。
2019 年，全球青少年和年轻人中有 281450 例 ALD 流行率、18930 例发病率和 3190 例死亡率。从 2000 年到 2019 年，年龄调整后的每 10 万人患病率在 25-29 岁年龄组中增加（APC：+0.6%，p=0.003），在 20-24 岁年龄组（p=0.302）和 15-19 岁年龄组（p=0.160）中保持稳定。15-19 岁至 20-24 岁年龄组（增加 19 倍）和 20-24 岁至 25-29 岁年龄组（增加 2.5 倍）的患病率显著增加。非洲和东地中海地区青少年和年轻人的所有年龄组的 ALD 流行率都有所增加。大约四分之三的国家和地区的年轻人中 ALD 发病率增加。
在过去二十年中，全球青少年和年轻人的 ALD 负担有所增加。该研究强调了制定旨在减少年轻人群体饮酒量和预防 ALD 的公共卫生政策的重要性。
