School of Stomatology, Shanxi Medical University, Taiyuan, Taiyuan, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, China.
Autoimmunity. 2024 Dec;57(1):2358070. doi: 10.1080/08916934.2024.2358070. Epub 2024 Jun 3.
Chronic periodontitis (CP) and allergic rhinitis (AR) have attracted wide attention as global public health problems with high incidence. Recent studies have shown that circulating interleukin-27 (IL-27) is associated with the risk of CP and AR. The aim of this study is to analyze the causal effect between them using Mendelian randomization (MR).
Bidirectional MR analyses were performed with the use of publicly available genome-wide association study (GWAS) data. Summary data on circulating IL-27, CP, and AR published in genome-wide association studies were collected. Instrumental variables (IV) were extracted using assumptions of correlation, independence and exclusivity as criteria. Inverse variance weighting (IVW) was used as the main method, combined with weighted median method (WM) and MR-Egger and other MR Analysis methods for causal inference of exposure and outcome. Cochran's Q and MR-Egger intercept were used for sensitivity analysis.
The IVW study showed a causal effect between increased circulating IL-27 levels and increased risk of CP (OR = 1.14, 95%CI = 1.02-1.26, = .020). Similarly, the increase of circulating IL-27 level had a causal effect on the decreased risk of AR (OR = 0.88, 95%CI = 0.80-0.97, = .012). In addition, IVW study found that there was a causal between the increased risk of CP and circulating IL-27 level (OR = 1.05, 95%CI = 1.01-1.10, = .016). However, there was no significant causal relationship between the risk of AR and circulating IL-27 levels (OR = 0.97, 95%CI = 0.91-1.02, = .209). no significant heterogeneity or horizontal pleiotropy was found in sensitivity analysis.
There is a causal effect between circulating IL-27 level and CP, AR, which will help to find new ideas and methods for the diagnosis and treatment of CP and AR.
慢性牙周炎（CP）和过敏性鼻炎（AR）作为发病率较高的全球公共卫生问题受到广泛关注。最近的研究表明，循环白细胞介素-27（IL-27）与 CP 和 AR 的发病风险相关。本研究旨在使用孟德尔随机化（MR）分析它们之间的因果关系。
使用公开的全基因组关联研究（GWAS）数据进行双向 MR 分析。收集已发表的关于循环 IL-27、CP 和 AR 的 GWAS 汇总数据。根据相关性、独立性和排他性假设提取工具变量（IV）。使用逆方差加权（IVW）作为主要方法，结合加权中位数法（WM）和 MR-Egger 等其他 MR 分析方法进行暴露和结局的因果推断。采用 Cochran's Q 和 MR-Egger 截距进行敏感性分析。
IVW 研究表明，循环 IL-27 水平升高与 CP 风险增加之间存在因果关系（OR=1.14，95%CI=1.02-1.26，=0.020）。同样，循环 IL-27 水平升高对 AR 风险降低也有因果关系（OR=0.88，95%CI=0.80-0.97，=0.012）。此外，IVW 研究发现 CP 发病风险与循环 IL-27 水平之间存在因果关系（OR=1.05，95%CI=1.01-1.10，=0.016）。然而，AR 发病风险与循环 IL-27 水平之间没有显著的因果关系（OR=0.97，95%CI=0.91-1.02，=0.209）。敏感性分析未发现显著异质性或水平多效性。
循环 IL-27 水平与 CP、AR 之间存在因果关系，这将有助于为 CP 和 AR 的诊断和治疗提供新的思路和方法。
