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在特发性肾病综合征患儿中，基于既往史免疫接种 13 价肺炎球菌结合疫苗的免疫原性、免疫记忆和疾病活动监测。

Immunogenicity, Immunological Memory and Monitoring of Disease Activity Following an Anamnestic Immunization With the 13-Valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome.

机构信息

Immunobiology and Vaccinology Research Laboratory, First Department of Pediatrics, "Aghia Sophia" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Department of Nephrology, "P. and A. Kyriakou" Children's Hospital, Athens, Greece.

出版信息

J Pediatric Infect Dis Soc. 2024 Jul 20;13(7):363-367. doi: 10.1093/jpids/piae057.

DOI:10.1093/jpids/piae057
PMID:38829802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11260040/
Abstract

Anamnestic 13-valent pneumococcal conjugate vaccine immunization did not affect the relapse risk in pediatric idiopathic nephrotic syndrome. Pneumococcal serotype (PS)-specific antibody titers increased significantly in all groups. Children receiving immunomodulatory treatments (IMTs) displayed significantly lower levels of PS-specific antibodies for 3/8 serotypes tested. PS-specific B-cell counts significantly increased only in healthy controls and patients receiving corticosteroids.

摘要

疫苗接种史对儿童特发性肾病综合征的复发风险无影响。所有组的肺炎球菌血清型（PS）特异性抗体滴度均显著升高。接受免疫调节治疗（IMTs）的儿童在 8 种 PS 特异性抗体中，有 3 种的抗体水平显著较低。仅在健康对照组和接受皮质类固醇治疗的患者中，PS 特异性 B 细胞计数显著增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f830/11260040/56133733e278/piae057_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f830/11260040/56133733e278/piae057_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f830/11260040/56133733e278/piae057_fig1.jpg

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本文引用的文献

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20‑Valent Pneumococcal Conjugate Vaccine: Pediatric First Approval.20 价肺炎球菌结合疫苗：儿科首次批准。
Paediatr Drugs. 2023 Sep;25(5):613-619. doi: 10.1007/s40272-023-00584-9.
2
Development of a novel flow cytometry method for detecting pneumococcal-specific B cells.开发一种新型流式细胞术方法检测肺炎球菌特异性 B 细胞。
Cytometry A. 2022 Jul;101(7):588-596. doi: 10.1002/cyto.a.24654. Epub 2022 May 24.
3
Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases.KDIGO 2021肾小球疾病管理指南执行摘要。
Kidney Int. 2021 Oct;100(4):753-779. doi: 10.1016/j.kint.2021.05.015.
4
Evaluation of Immune and Vaccine Competence in Steroid-Sensitive Nephrotic Syndrome Pediatric Patients.激素敏感型肾病综合征患儿免疫及疫苗接种能力评估
Front Immunol. 2021 Mar 12;12:602826. doi: 10.3389/fimmu.2021.602826. eCollection 2021.
5
Increased pathogenicity of pneumococcal serotype 1 is driven by rapid autolysis and release of pneumolysin.肺炎链球菌 1 型致病性增加是由快速自溶和释放肺炎球菌溶血素驱动的。
Nat Commun. 2020 Apr 20;11(1):1892. doi: 10.1038/s41467-020-15751-6.
6
The Role of Serotype-Specific Immunological Memory in Pneumococcal Vaccination: Current Knowledge and Future Prospects.血清型特异性免疫记忆在肺炎球菌疫苗接种中的作用：当前认知与未来展望
Vaccines (Basel). 2019 Jan 29;7(1):13. doi: 10.3390/vaccines7010013.
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Polyvalent vaccines: High-maintenance heroes.多价疫苗：需要精心维护的“英雄”。
PLoS Pathog. 2018 Apr 5;14(4):e1006904. doi: 10.1371/journal.ppat.1006904. eCollection 2018 Apr.
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