在特发性肾病综合征患儿中，基于既往史免疫接种 13 价肺炎球菌结合疫苗的免疫原性、免疫记忆和疾病活动监测。
Immunogenicity, Immunological Memory and Monitoring of Disease Activity Following an Anamnestic Immunization With the 13-Valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome.
机构信息
Immunobiology and Vaccinology Research Laboratory, First Department of Pediatrics, "Aghia Sophia" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Department of Nephrology, "P. and A. Kyriakou" Children's Hospital, Athens, Greece.
出版信息
J Pediatric Infect Dis Soc. 2024 Jul 20;13(7):363-367. doi: 10.1093/jpids/piae057.
Anamnestic 13-valent pneumococcal conjugate vaccine immunization did not affect the relapse risk in pediatric idiopathic nephrotic syndrome. Pneumococcal serotype (PS)-specific antibody titers increased significantly in all groups. Children receiving immunomodulatory treatments (IMTs) displayed significantly lower levels of PS-specific antibodies for 3/8 serotypes tested. PS-specific B-cell counts significantly increased only in healthy controls and patients receiving corticosteroids.
疫苗接种史对儿童特发性肾病综合征的复发风险无影响。所有组的肺炎球菌血清型（PS）特异性抗体滴度均显著升高。接受免疫调节治疗（IMTs）的儿童在 8 种 PS 特异性抗体中，有 3 种的抗体水平显著较低。仅在健康对照组和接受皮质类固醇治疗的患者中，PS 特异性 B 细胞计数显著增加。
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