From the Department of Cardiology (AlRahimi, Ismail, Ahmed, Haneef); from the Department of Cardiothoracic Surgery (Haneef), King Abdulaziz Medical City, Ministry of National Guard Health Affairs, from King Abdullah International Medical Research Center (AlRahimi, Ismail, Aljubairi, Kutob, Bakulka), from the College of Medicine (AlRahimi); from the College of Applied Medical Sciences (Ismail, Aljubairi, Kutob, Bakulka), King Saud bin Abdulaziz University for Health Sciences, and from the College of Medicine (Ahmed), Batterjee Medical College for Science and Technology, Jeddah, Kingdom of Saudi Arabia.
Saudi Med J. 2024 Jun;45(6):572-577. doi: 10.15537/smj.2024.45.6.20240071.
To evaluate the relationship between severity of tricuspid regurgitation (TR) and pulmonary hypertension.
Cross-sectional study of 118 patients with pulmonary hypertension was carried out at a single center in Jeddah, Saudi Arabia, between 2018-2021. Patients who had pulmonary or tricuspid valves organic diseases, previously undergone tricuspid or pulmonary valve surgeries, had permanent pacemakers or critically ill were excluded.
A high proportion of patients were women (n=100, 85%) and obese (n=57, 48%). Patients with more than mild TR had higher systolic pulmonary artery pressure (sPAP) than those with trivial or mild regurgitation (<0.001). There was a significant association between severity of TR (<0.001) and right chambers size (=0.001). Furthermore, pulmonary artery pressure (PAP) was significantly higher in patients with mild right ventricular impairment (=0.001).
Increase in degree of TR and right atrial size were predictors of elevated sPAP. Our findings highlight the interplay among TR, right heart size, ventricular function, and PAP. Understanding these associations can aid in risk stratification, monitoring disease progression, and potentially guiding treatment in those patients.
评估三尖瓣反流（TR）严重程度与肺动脉高压之间的关系。
在沙特阿拉伯吉达的一家单中心进行了一项横断面研究，共纳入 118 例肺动脉高压患者，研究时间为 2018 年至 2021 年。排除患有肺或三尖瓣器质性疾病、曾行三尖瓣或肺动脉瓣手术、有永久性起搏器或病危的患者。
大多数患者为女性（n=100，85%）和肥胖患者（n=57，48%）。与轻度或无反流（TR）患者相比，中重度 TR 患者的收缩期肺动脉压（sPAP）更高（<0.001）。TR 严重程度（<0.001）与右心房大小之间存在显著相关性（=0.001）。此外，轻度右心室功能障碍患者的肺动脉压（PAP）显著升高（=0.001）。
TR 程度和右心房增大是 sPAP 升高的预测因素。我们的发现强调了 TR、右心大小、心室功能和 PAP 之间的相互作用。了解这些关联有助于对患者进行风险分层、监测疾病进展，并可能指导治疗。
