TCS Research, Tata Consultancy Services Ltd., TCS SP2 SEZ, Hinjewadi Phase 3, Pune 411057, India.
CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
J Appl Microbiol. 2024 Jun 3;135(6). doi: 10.1093/jambio/lxae130.
Understanding disease pathogenesis caused by bacteria/virus, from the perspective of individual pathogen has provided meaningful insights. However, as viral and bacterial counterparts might inhabit the same infection site, it becomes crucial to consider their interactions and contributions in disease onset and progression. The objective of the review is to highlight the importance of considering both viral and bacterial agents during the course of coinfection. The review provides a unique perspective on the general theme of virus-bacteria interactions, which either lead to colocalized infections that are restricted to one anatomical niche, or systemic infections that have a systemic effect on the human host. The sequence, nature, and underlying mechanisms of certain virus-bacteria interactions have been elaborated with relevant examples from literature. It also attempts to address the various applied aspects, including diagnostic and therapeutic strategies for individual infections as well as virus-bacteria coinfections. The review aims to aid researchers in comprehending the intricate interplay between virus and bacteria in disease progression, thereby enhancing understanding of current methodologies and empowering the development of novel health care strategies to tackle coinfections.
从个体病原体的角度理解细菌/病毒引起的疾病发病机制提供了有意义的见解。然而，由于病毒和细菌可能栖息在相同的感染部位，因此必须考虑它们在疾病发生和进展中的相互作用和贡献。本综述的目的是强调在合并感染过程中同时考虑病毒和细菌病原体的重要性。本综述从一般的病毒-细菌相互作用主题提供了一个独特的视角，这些相互作用要么导致局限于一个解剖部位的局部感染，要么导致对人类宿主产生全身性影响的全身性感染。本文通过文献中的相关实例详细阐述了某些病毒-细菌相互作用的顺序、性质和潜在机制。它还试图解决各种应用方面的问题，包括个体感染和病毒-细菌合并感染的诊断和治疗策略。本综述旨在帮助研究人员理解疾病进展中病毒和细菌之间的复杂相互作用，从而增强对现有方法的理解，并为解决合并感染问题提供新的医疗保健策略。
