从布基纳法索人体病理液中分离出的金黄色葡萄球菌的新闻序列类型。
News sequences types of Staphylococcus aureus isolated from human pathologicals fluids in Burkina Faso.
机构信息
Laboratoire de Biochimie et Immunologie Appliquées (LaBIA) au Burkina Faso, Université Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso.
Laboratoire de Bactériologie Hôpital Armaud de Villeneuve-CHU de Montpellier, 191 Avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France.
出版信息
BMC Res Notes. 2024 Jun 3;17(1):151. doi: 10.1186/s13104-024-06805-9.
Staphylococcus aureus is a pathogen with high epidemic potential frequently involved in nosocomials and communities infections. The pathogenicity of Staphylococcus aureus is due to both its ability to resist antibiotics and to Produce toxins. This work aims at studying the resistance and Molecular Epidemiology of Staphylococcus aureus. Antibiotic susceptibility of the 70 strains isolates of Staphylococcus aureus was determined by agar diffusion while Multiplex PCR and MLST were used to search toxin-coding genes and MRSA typing, respectively. 14.28% of isolates were multidrug resistant. Staphylococcus aureus showed high susceptibility to aminoglycoside and Macrolides familly. lukS-PV/lukF-PV and sea genes were detected in 45% and 3% of Staphylococcus aureus respectively. Ten (10) sequence types including ST5710, ST2430, ST5289, ST5786, ST6942, ST6943, ST6944, ST6945, ST6946, ST6947 have been reported. The study showed a diversity of antibiotic resistance phenotypes and a great diversity of MRSA clones causing infections.
金黄色葡萄球菌是一种具有高流行潜力的病原体，经常涉及医院和社区感染。金黄色葡萄球菌的致病性既与其抵抗抗生素的能力有关，也与其产生毒素的能力有关。本工作旨在研究金黄色葡萄球菌的耐药性和分子流行病学。采用琼脂扩散法测定 70 株金黄色葡萄球菌分离株的抗生素敏感性，采用多重 PCR 和 MLST 分别搜索毒素编码基因和 MRSA 分型。14.28%的分离株为多药耐药。金黄色葡萄球菌对氨基糖苷类和大环内酯类家族表现出高度敏感性。在 45%的金黄色葡萄球菌中检测到 lukS-PV/lukF-PV 和 sea 基因，分别为 3%。报告了 10 种（10）序列类型，包括 ST5710、ST2430、ST5289、ST5786、ST6942、ST6943、ST6944、ST6945、ST6946 和 ST6947。研究表明，感染金黄色葡萄球菌的抗生素耐药表型和 MRSA 克隆多样性很大。
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