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载有万古霉素和 BMP-2 的β-TCP 陶瓷与 ADA 明胶复合材料的双重释放。

Dual release of daptomycin and BMP-2 from a composite of β-TCP ceramic and ADA gelatin.

机构信息

G.E.R.N. Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center- Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.

Institute of Microbiology and Hygiene, Faculty of Medicine, Medical Center Albert-Ludwigs-University of Freiburg, Hermann- Herder-Straße 11, 79104, Freiburg, Germany.

出版信息

BMC Biotechnol. 2024 Jun 3;24(1):38. doi: 10.1186/s12896-024-00863-4.

DOI:10.1186/s12896-024-00863-4
PMID:38831403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11149308/
Abstract

BACKGROUND: Antibiotic-containing carrier systems are one option that offers the advantage of releasing active ingredients over a longer period of time. In vitro sustained drug release from a carrier system consisting of microporous β-TCP ceramic and alginate has been reported in previous works. Alginate dialdehyde (ADA) gelatin gel showed both better mechanical properties when loaded into a β-TCP ceramic and higher biodegradability than pure alginate. METHODS: Dual release of daptomycin and BMP-2 was measured on days 1, 2, 3, 6, 9, 14, 21, and 28 by HPLC and ELISA. After release, the microbial efficacy of the daptomycin was verified and the biocompatibility of the composite was tested in cell culture. RESULTS: Daptomycin and the model compound FITC protein A (n = 30) were released from the composite over 28 days. A Daptomycin release above the minimum inhibitory concentration (MIC) by day 9 and a burst release of 71.7 ± 5.9% were observed in the loaded ceramics. Low concentrations of BMP-2 were released from the loaded ceramics over 28 days.

摘要

背景：含抗生素载体系统是一种提供活性成分更长时间释放优势的选择。先前的研究报道了由微孔β-TCP 陶瓷和藻酸盐组成的载体系统中抗生素的体外持续药物释放。与纯藻酸盐相比，ADA 明胶凝胶负载到β-TCP 陶瓷中时显示出更好的机械性能和更高的生物降解性。 方法：通过 HPLC 和 ELISA 在第 1、2、3、6、9、14、21 和 28 天测量达托霉素和 BMP-2 的双重释放。释放后，验证达托霉素的微生物功效，并在细胞培养中测试复合材料的生物相容性。 结果：达托霉素和模型化合物 FITC 蛋白 A（n=30）在 28 天内从复合材料中释放出来。在负载陶瓷中，第 9 天观察到达托霉素释放量超过最小抑菌浓度（MIC），并出现 71.7±5.9%的爆发式释放。负载陶瓷中持续释放低浓度的 BMP-2。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/9021f91d0f89/12896_2024_863_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/a511c17ad5eb/12896_2024_863_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/b2c7a01a5bf2/12896_2024_863_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/c7b7ed070d1b/12896_2024_863_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/59058455b4f2/12896_2024_863_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/9021f91d0f89/12896_2024_863_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/a511c17ad5eb/12896_2024_863_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/b2c7a01a5bf2/12896_2024_863_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/c7b7ed070d1b/12896_2024_863_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/59058455b4f2/12896_2024_863_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a90/11149308/9021f91d0f89/12896_2024_863_Fig5_HTML.jpg

相似文献

[1]
Dual release of daptomycin and BMP-2 from a composite of β-TCP ceramic and ADA gelatin.

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[2]
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本文引用的文献

[1]
Composite material consisting of microporous beta-TCP ceramic and alginate-dialdehyde-gelatin for controlled dual release of clindamycin and bone morphogenetic protein 2.

J Mater Sci Mater Med. 2023-7-27

[2]
Alternative Geometries for 3D Bioprinting of Calcium Phosphate Cement as Bone Substitute.

Biomedicines. 2022-12-13

[3]
Gelatin Nanoparticles for Targeted Dual Drug Release out of Alginate-di-Aldehyde-Gelatin Gels.

Gels. 2022-6-8

[4]
A human bone infection organ model for biomaterial research.

Acta Biomater. 2022-5

[5]
Mechanical Properties of the Composite Material consisting of β-TCP and Alginate-Di-Aldehyde-Gelatin Hydrogel and Its Degradation Behavior.

Materials (Basel). 2021-3-9

[6]
The Crossroads between Infection and Bone Loss.

Microorganisms. 2020-11-10

[7]
Fabrication of alginate-gelatin crosslinked hydrogel microcapsules and evaluation of the microstructure and physico-chemical properties.

J Mater Chem B. 2014-3-21

[8]
Osteomyelitis.

Infect Dis Clin North Am. 2017-6

[9]
Composite material consisting of microporous β-TCP ceramic and alginate for delayed release of antibiotics.

Acta Biomater. 2017-3-15

[10]
Sustained release of rhBMP-2 from microporous tricalciumphosphate using hydrogels as a carrier.

BMC Biotechnol. 2016-5-20

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