Podger D M, Hall R M
Mutat Res. 1985 Mar;142(3):87-91. doi: 10.1016/0165-7992(85)90045-4.
Reversion of the Salmonella typhimurium frameshift marker hisC3076 by ICR191 and 9-aminoacridine in rec+ and recA1 backgrounds was examined using the standard plate-reversion assay. For both compounds, the level of reversion observed in the recA strain is significantly greater than in the rec+ strain. Thus reversion of hisC3076 is not recA-dependent, but is recA-modulated. The ability of a mutagen (or mutagenic treatment) to induce the recA lexA-dependent SOS response does not therefore imply that mutagenic effects will also be recA-dependent.
利用标准平板回复突变试验，检测了在rec⁺和recA1背景下，ICR191和9-氨基吖啶对鼠伤寒沙门氏菌移码标记hisC3076的回复突变情况。对于这两种化合物，在recA菌株中观察到的回复突变水平显著高于rec⁺菌株。因此，hisC3076的回复突变不依赖recA，但受recA调节。诱变剂（或诱变处理）诱导recA lexA依赖性SOS反应的能力，并不意味着诱变效应也将依赖recA。
