Kharab P, Singh I
Mutat Res. 1985 Mar;155(3):117-20. doi: 10.1016/0165-1218(85)90128-4.
4 metal salts, potassium dichromate, sodium arsenite, cobalt chloride and lead nitrate were tested for their genotoxic effects in Saccharomyces cerevisiae. Potassium dichromate was the most potent agent for induction of gene conversion and reverse mutation. Sodium arsenite was virtually ineffective as a convertogen but gave a positive result for reversion. Cobalt chloride was the least toxic, exhibited a convertogenic activity but was only marginally active for reverse mutation. Lead nitrate was the most toxic salt but was genetically inactive.
对4种金属盐，即重铬酸钾、亚砷酸钠、氯化钴和硝酸铅，进行了它们对酿酒酵母遗传毒性作用的测试。重铬酸钾是诱导基因转换和回复突变的最有效试剂。亚砷酸钠作为转换剂实际上无效，但回复突变结果呈阳性。氯化钴毒性最小，表现出转换活性，但对回复突变仅有微弱活性。硝酸铅是毒性最大的盐，但无遗传活性。
