Li Xiao-Long, Yu Xiao-Yu, Tao Yu-Ao, Xu Yu-Zhu, Li Xi, Wang Jia-Dong, Zhang Le-Le, Wang Yun-Tao, Fan Pan
Department of Spine Center, Zhongda Hospital, Medical School, Southeast University, China.
Department of gynecology and obstetrics, The Affiliated Jiangning Hospital of Nanjing Medical University, China.
Curr Med Chem. 2025;32(17):3405-3422. doi: 10.2174/0109298673287391231228081400.
Intervertebral disc degeneration (IDD) is a common musculoskeletal system disease, which is one of the most important causes of low back pain. Despite the high prevalence of IDD, current treatments are limited to relieving symptoms, and there are no effective therapeutic agents that can block or reverse the progression of IDD. Oxidative stress, the result of an imbalance between the production of reactive oxygen species (ROS) and clearance by the antioxidant defense system, plays an important role in the progression of IDD. Polyphenols are antioxidant compounds that can inhibit ROS production, which can scavenge free radicals, reduce hydrogen peroxide production, and inhibit lipid oxidation in nucleus pulposus (NP) cells and IDD animal models. In this review, we discussed the antioxidant effects of polyphenols and their regulatory role in different molecular pathways associated with the pathogenesis of IDD, as well as the limitations and future prospects of polyphenols as a potential treatment of IDD.
椎间盘退变（IDD）是一种常见的肌肉骨骼系统疾病，是腰痛的最重要原因之一。尽管IDD的患病率很高，但目前的治疗仅限于缓解症状，尚无有效的治疗药物能够阻止或逆转IDD的进展。氧化应激是活性氧（ROS）产生与抗氧化防御系统清除之间失衡的结果，在IDD的进展中起重要作用。多酚是一类抗氧化化合物，能够抑制ROS的产生，清除自由基，减少过氧化氢的生成，并抑制髓核（NP）细胞和IDD动物模型中的脂质氧化。在本综述中，我们讨论了多酚的抗氧化作用及其在与IDD发病机制相关的不同分子途径中的调节作用，以及多酚作为IDD潜在治疗方法的局限性和未来前景。
