Chalas J, Labayle D, Macarrio J, Barraud D, Lindenbaum A, Buffet C, Chaput J C
Pathol Biol (Paris). 1979 Sep;27(7):411-6.
In cirrhotic patients, the authors studied the modification of the pharmacokinetics of ampicillin in the plasma and in the ascitic fluid, as well as its concentration in the urine. The influence of the jaundice, the ascites and diuretics were studied. In cirrhosis, dilution and elimination of the antibiotic are modified, as is shown by the increase in T 1/2 alpha and T 1/2 beta. These anomalies seem to be due essentially to modifications in the distribution volume; the degree of hepatocellular insufficiency does not appear to be of importance. The ascites acts as an independent compartment, into which the antibiotic's passage in slight. The practical consequences are the following: less frequent injections, increasing of the fractionated doses, in situ injections of ampicillin in cases of infection of the ascitic liquid.
在肝硬化患者中，作者研究了氨苄西林在血浆和腹水中的药代动力学变化及其在尿液中的浓度。研究了黄疸、腹水和利尿剂的影响。在肝硬化中，抗生素的稀释和消除发生改变，如α半衰期和β半衰期的延长所示。这些异常似乎主要归因于分布容积的改变；肝细胞功能不全的程度似乎并不重要。腹水起到一个独立腔室的作用，抗生素进入其中的量很少。实际后果如下：注射频率降低，分次剂量增加，在腹水感染的情况下进行氨苄西林原位注射。
