Fan Zhen, Khizar Hayat, Lu Jinjiao, Wang Anhua, Xun Tong, Zhang Xiao, Zhao Hongfeng
Department of Gastroenterology Hangzhou First People's Hospital Hangzhou China.
The Fourth School of Clinical Medicine Zhejiang Chinese Medical University Hangzhou China.
JGH Open. 2024 Jun 2;8(6):e13080. doi: 10.1002/jgh3.13080. eCollection 2024 Jun.
Alendronate is used to treat Paget's bone disease, glucocorticoid-induced osteoporosis, and postmenopausal osteoporosis because it suppresses osteoclast activity to stop bone resorption.
We present an exceptional case of esophagitis caused by alendronate. Blood tests and other data were normal when the patient was taken to the hospital, but an endoscopic examination revealed significant esophageal redness, erosion, and ulceration, along with pseudomembrane. The patient was given medicine after receiving a diagnosis of alendronate pill-induced esophagitis based on the pathological findings.
This case report is a timely reminder of the importance of thorough pharmacovigilance, patient education, and smart therapeutic decision-making in the context of alendronate use. To properly treat and prevent problems with the esophagus caused by alendronate, additional research is required.
阿仑膦酸盐用于治疗佩吉特骨病、糖皮质激素诱导的骨质疏松症和绝经后骨质疏松症，因为它能抑制破骨细胞活性以阻止骨吸收。
我们呈现了一例由阿仑膦酸盐引起的食管炎特殊病例。患者入院时血液检查及其他数据均正常，但内镜检查显示食管有明显发红、糜烂、溃疡及假膜形成。根据病理结果诊断为阿仑膦酸盐片所致食管炎后，给予患者药物治疗。
本病例报告及时提醒了在使用阿仑膦酸盐时进行全面药物警戒、患者教育及明智治疗决策的重要性。为妥善治疗和预防阿仑膦酸盐引起的食管问题，还需要进一步研究。
