Patel Iva, Vyas Pooja, Natarajan Karthik, Kanabar Kewal, Sharma Vishal, Jain Sharad, Joshi Dinesh, Dahiya Swati, Borra Siva N
Research Department, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India.
Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre (UNMICRC), Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India.
J Saudi Heart Assoc. 2024 May 8;36(1):34-41. doi: 10.37616/2212-5043.1372. eCollection 2024.
The study was aimed to evaluate gender difference and age & gender specific interaction of in-hospital outcomes of patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).
This was a prospective cohort study of 1748 patients with STEMI undergoing primary PCI. The study was dichotomised according to gender to evaluate the difference in the outcome. The study was further stratified based on an age cut-off of 75 years to examine the age-specific gender relationship in survival outcomes. Independent variables for in-hospital mortality were analysed through logistic regression.
There were 314 (17.96%) females with an average age of 60.80 years and 1434 (82.03%) males with an average age of 54.87 years. The prevalence of diabetes (24.8% vs. 13.2%) and hypertension (33.1% vs. 12.9%) was significantly higher in female patients compared to male patients, whereas the significantly higher number of male patients were smokers. On multivariate analysis, odds of female gender OR = 3.54 (1.37-9.17), killip class >2 OR = 3.05 (1.97-4.71) and baseline creatinine OR = 2.27 (1.22-4.23) were found as significant predictors of in-hospital mortality. The crude odds ratio of 2.35 (1.49-3.72) and adjusted OR of 2.05 (1.27-3.30) for female mortality was significant among patients aged <75-years. While patients with ≥75-years of age, the mortality difference was insignificant.
Although the incidence of STEMI was higher in male compared to female patients, female patients had two-fold higher in-hospital mortality than male. Female gender was an independent predictor for in-hospital mortality in patients <75-years of age.
本研究旨在评估接受直接经皮冠状动脉介入治疗（PCI）的ST段抬高型心肌梗死（STEMI）患者的院内结局的性别差异以及年龄与性别的特定相互作用。
这是一项对1748例接受直接PCI的STEMI患者进行的前瞻性队列研究。根据性别将研究分为两组以评估结局差异。根据75岁的年龄界限进一步分层，以研究生存结局中特定年龄的性别关系。通过逻辑回归分析院内死亡的独立变量。
有314名（17.96%）女性，平均年龄60.80岁，1434名（82.03%）男性，平均年龄54.87岁。女性患者的糖尿病患病率（24.8%对13.2%）和高血压患病率（33.1%对12.9%）显著高于男性患者，而男性患者中吸烟者数量显著更多。多变量分析显示，女性性别比值比（OR）=3.54（1.37 - 9.17）、Killip分级>2 OR = 3.05（1.97 - 4.71）和基线肌酐OR = 2.
