Wladimiroff J W, Beemer F A, Scholtmeyer R J, Stewart P A, Spritzer R, Wolff E D
Prenat Diagn. 1985 Jan-Feb;5(1):41-6. doi: 10.1002/pd.1970050108.
The prenatal diagnosis, management and outcome of an hereditary obstructive uropathy is presented. Serial ultrasonic assessment of the fetal urinary tract was carried out from the early second trimester onward. Slight bilateral hydronephrosis as a first sign of obstructive uropathy was only established as late as 30 weeks of gestation. On the basis of weekly ultrasound scans, a conservative approach was adopted. In view of fetal maturity, labour was induced at 36 weeks resulting in the vaginal delivery of a male infant with moderate bilateral hydronephrosis. Neonatally, anuria developed due to bilateral obstruction of the ureters as a result of increasing bladder wall hypertrophy due to urethral valves. A bilateral uretero-cutaneostomy was carried out. The infant so far develops normally, and renal function is normal for age. Women at risk for fetal obstructive uropathy should have ultrasonic monitoring throughout pregnancy.
本文介绍了一例遗传性梗阻性尿路病的产前诊断、处理及结局。从孕中期早期开始对胎儿泌尿系统进行系列超声评估。梗阻性尿路病的首个征象——轻度双侧肾积水直到妊娠30周时才得以确定。基于每周的超声扫描结果，采取了保守治疗方法。鉴于胎儿已成熟，在36周时引产，经阴道分娩出一名患有中度双侧肾积水的男婴。出生后，由于尿道瓣膜导致膀胱壁肥厚加重，双侧输尿管梗阻，出现无尿。遂进行了双侧输尿管皮肤造口术。该婴儿目前发育正常，肾功能与其年龄相符。有胎儿梗阻性尿路病风险的孕妇在整个孕期都应接受超声监测。
