亚麻醉剂量氯胺酮抑制蓝斑介导的警觉效应：7T fMRI 研究。
Subanesthetic Ketamine Suppresses Locus Coeruleus-Mediated Alertness Effects: A 7T fMRI Study.
机构信息
Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany.
University Clinic for Dermatology, Magdeburg, Germany.
出版信息
Int J Neuropsychopharmacol. 2024 Jun 1;27(6). doi: 10.1093/ijnp/pyae022.
BACKGROUND
The NMDA antagonist S-ketamine is gaining increasing use as a rapid-acting antidepressant, although its exact mechanisms of action are still unknown. In this study, we investigated ketamine in respect to its properties toward central noradrenergic mechanisms and how they influence alertness behavior.
METHODS
We investigated the influence of S-ketamine on the locus coeruleus (LC) brain network in a placebo-controlled, cross-over, 7T functional, pharmacological MRI study in 35 healthy male participants (25.1 ± 4.2 years) in conjunction with the attention network task to measure LC-related alertness behavioral changes.
RESULTS
We could show that acute disruption of the LC alertness network to the thalamus by ketamine is related to a behavioral alertness reduction.
CONCLUSION
The results shed new light on the neural correlates of ketamine beyond the glutamatergic system and underpin a new concept of how it may unfold its antidepressant effects.
背景
NMDA 拮抗剂 S-氯胺酮作为一种快速起效的抗抑郁药，使用日益增多，但其确切作用机制仍不清楚。在这项研究中，我们研究了氯胺酮对中枢去甲肾上腺素能机制的作用及其对警觉行为的影响。
方法
我们在 35 名健康男性参与者（25.1±4.2 岁）中进行了一项安慰剂对照、交叉、7T 功能、药物 fMRI 研究，以注意力网络任务测量与蓝斑相关的警觉行为变化，来研究 S-氯胺酮对蓝斑核（LC）脑网络的影响。
结果
我们发现，氯胺酮对 LC 向丘脑的警觉网络的急性破坏与行为警觉性降低有关。
结论
这些结果为氯胺酮在谷氨酸能系统之外的神经相关性提供了新的认识，并为其发挥抗抑郁作用的机制提供了新概念。
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