Wang Lin, Qin Wenhui
Institute of Frontier Chemistry School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, P. R. China.
Org Lett. 2024 Jun 14;26(23):5049-5054. doi: 10.1021/acs.orglett.4c01768. Epub 2024 Jun 4.
A copper-catalyzed regiodivergent chloropentafluorosulfanylation strategy for 1,3-enynes using SFCl has been developed. The regioselectivity is dictated by the structural and substitution patterns of 1,3-enynes, enabling facile access to three classes of SF-containing products: propargylic chlorides, 1,3-dienes, and allenes. The reaction systems involve radical species, where the transfer of a chlorine atom from SFCl to a carbon radical is considered the predominant pathway. Diverse types of SF- building blocks can be synthesized through simple functional group transformations.
已开发出一种使用SFCl对1,3-烯炔进行铜催化的区域发散性氯五氟硫烷基化策略。区域选择性由1,3-烯炔的结构和取代模式决定，能够轻松获得三类含SF的产物：炔丙基氯、1,3-二烯和丙二烯。反应体系涉及自由基物种，其中氯原子从SFCl转移到碳自由基被认为是主要途径。通过简单的官能团转化可以合成多种类型的含SF结构单元。
