Laboratory of Human Higher Nervous Activity, Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia; Centre for Cognition & Decision Making, Institute for Cognitive Neuroscience, National Research University Higher School of Economics, Moscow, Russia.
Laboratory of Human Higher Nervous Activity, Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia; Sirius Center for Cognitive Sciences, Sirius University of Science and Technology, Sochi, Russia.
Psychiatry Res Neuroimaging. 2024 Aug;342:111828. doi: 10.1016/j.pscychresns.2024.111828. Epub 2024 May 22.
Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) are psychiatric disorders that often co-occur. We aimed to investigate whether their high comorbidity could be traced not only by clinical manifestations, but also at the level of functional brain activity. In this paper, we examined the differences in functional connectivity (FC) at the whole-brain level and within the default mode network (DMN). Resting-state EEG was obtained from 43 controls, 26 OCD patients, and 34 MDD patients. FC was analyzed between 68 cortical sources, and between-group differences in the 4-30 Hz range were assessed via the Network Based Statistic method. The strength of DMN intra-connectivity was compared between groups in the theta, alpha and beta frequency bands. A cluster of 67 connections distinguished the OCD, MDD and control groups. The majority of the connections, 8 of which correlated with depressive symptom severity, were found to be weaker in the clinical groups. Only 3 connections differed between the clinical groups, and one of them correlated with OCD severity. The DMN strength was reduced in the clinical groups in the alpha and beta bands. It can be concluded that the high comorbidity of OCD and MDD can be traced at the level of FC.
重度抑郁症（MDD）和强迫症（OCD）是经常同时发生的精神疾病。我们旨在研究它们的高共病性不仅可以通过临床表现来追踪，还可以通过功能脑活动水平来追踪。在本文中，我们检查了全脑水平和默认模式网络（DMN）内功能连接（FC）的差异。从 43 名对照者、26 名强迫症患者和 34 名重度抑郁症患者中获得静息状态 EEG。在 68 个皮质源之间分析了 FC，并通过基于网络的统计方法评估了 4-30 Hz 范围内的组间差异。在 theta、alpha 和 beta 频带中比较了组间 DMN 内连接的强度。一个由 67 个连接组成的簇将 OCD、MDD 和对照组区分开来。大多数连接（其中 8 个与抑郁症状严重程度相关）在临床组中较弱。临床组之间只有 3 个连接不同，其中一个与 OCD 严重程度相关。DMN 在临床组中的 alpha 和 beta 频段的强度降低。可以得出结论，OCD 和 MDD 的高共病性可以在 FC 水平上进行追踪。
