Department of Nuclear Medicine, .
Department of Radiation Oncology, Bezmialem Vakif University Faculty of Medicine, .
Nucl Med Commun. 2024 Jul 1;45(7):629-641. doi: 10.1097/MNM.0000000000001851. Epub 2024 Apr 27.
To investigate the relationship between intraprostatic 68Ga-prostate-specific membrane antigen (PSMA) uptake values and volumetric parameters derived from early pelvic and standard-time whole-body 68Ga-PSMA PET/computed tomography (CT) images in untreated prostate cancer (PCa) patients, and to assess the predictive significance of these data in relation to disease prognosis, comparing them with the Gleason score, clinical risk classification and the presence of metastatic disease detected in 68Ga-PSMA PET/CT imaging.
Eighty-one newly diagnosed PCa patients underwent early phase pelvic imaging at the 5th minute and standard time whole-body imaging at the 60th minute. Various threshold values were used in intraprostatic delineations to compute maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), intraprostatic PSMA tumor volume and intraprostatic total lesion PSMA uptake. Correlations between early and standard time measurements, as well as changes in SUV parameters over time, were examined. The association of these values with Gleason score, clinical risk status (National Comprehensive Cancer Network), and metastatic disease was explored.
SUVmax measurements from both early and standard time images distinguished all three groups (clinical risk scores, Gleason score and metastatic group), with standard imaging demonstrating statistical superiority in receiver operating characteristic analyses. Strong correlations were observed between early and standard-time PET parameters. Changes in intraprostatic SUVmax and SUVmean values over time did not exhibit predictive value.
Although intraprostatic PSMA PET parameters generally aligned at both early and standard times, parameters obtained from standard time images showed more robust correlations with clinical risk scores, Gleason score and metastasis status in newly diagnosed, untreated PCa patients.
探讨未经治疗的前列腺癌（PCa）患者前列腺内 68Ga-前列腺特异性膜抗原（PSMA）摄取值与早期盆腔和标准时间全身 68Ga-PSMA PET/CT 图像的体积参数之间的关系，并评估这些数据与疾病预后的预测意义，将其与 Gleason 评分、临床风险分类和 68Ga-PSMA PET/CT 成像中检测到的转移性疾病进行比较。
81 例新诊断的 PCa 患者接受了第 5 分钟的早期盆腔成像和第 60 分钟的标准时间全身成像。在前列腺内勾画中使用各种阈值来计算最大标准化摄取值（SUVmax）、平均标准化摄取值（SUVmean）、前列腺内 PSMA 肿瘤体积和前列腺内总病变 PSMA 摄取。检查早期和标准时间测量之间的相关性以及 SUV 参数随时间的变化。探讨这些值与 Gleason 评分、临床风险状况（国家综合癌症网络）和转移性疾病的关系。
早期和标准时间图像的 SUVmax 测量值可区分所有三组（临床风险评分、Gleason 评分和转移组），标准成像在接受者操作特征分析中具有统计学优势。早期和标准时间 PET 参数之间存在很强的相关性。前列腺内 SUVmax 和 SUVmean 值随时间的变化没有显示出预测价值。
尽管前列腺内 PSMA PET 参数在早期和标准时间通常一致，但在新诊断、未经治疗的 PCa 患者中，标准时间图像获得的参数与临床风险评分、Gleason 评分和转移状态的相关性更强。
