酒渣鼻患者迟发型接触性超敏反应的评估
Evaluation of Delayed Contact Hypersensitivity in Patients with Rosacea.
作者信息
Alevizou Antigoni, Gregoriou Stamatios, Tsimpidakis Antonios, Pappa Georgia, Rigopoulos Dimitris, Katoulis Alexandros
机构信息
1st Department of Dermatology-Venereology, National and Kapodistrian University of Athens, Medical School, "Andreas Syggros" Hospital for Cutaneous and Venereal Diseases, Athens, Greece.
2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, "Attikon" General University Hospital, Athens, Greece.
出版信息
Skin Appendage Disord. 2024 Jun;10(3):207-214. doi: 10.1159/000536246. Epub 2024 Feb 2.
INTRODUCTION
Rosacea is a common chronic inflammatory dermatosis characterized by erythema, telangiectasia, papules, and pustules on the central face. The frequency of contact sensitization complicating rosacea and its therapy is unknown, with only few studies published in the literature. In the present study, we aimed to evaluate contact sensitivity in patients with rosacea.
METHODS
A total of 50 rosacea patients and 50 age- and sex-matched healthy controls were enrolled. Both groups were patch tested with the European Baseline Series.
RESULTS
A positive reaction to at least one allergen of the European Baseline Series was observed in 15 (30%) of rosacea patients and 10 (20%) of the healthy controls. Although the rate of positive reaction in the rosacea group was higher than in the controls, no statistically significant difference was documented. In addition, the total number of positive reactions to allergens in the rosacea group was higher than the control group, namely, 26 versus 17.
CONCLUSION
Contact hypersensitivity may coexist with rosacea. Its identification holds significant clinical relevance, influencing the long-term management and justifying the application of patch testing in rosacea patients.
引言
酒渣鼻是一种常见的慢性炎症性皮肤病，其特征为面部中央出现红斑、毛细血管扩张、丘疹和脓疱。酒渣鼻及其治疗并发接触致敏的频率尚不清楚，文献中仅有少数研究发表。在本研究中，我们旨在评估酒渣鼻患者的接触敏感性。
方法
共纳入50例酒渣鼻患者和50例年龄及性别匹配的健康对照。两组均用欧洲基线系列进行斑贴试验。
结果
15例（30%）酒渣鼻患者和10例（20%）健康对照对欧洲基线系列中至少一种变应原出现阳性反应。虽然酒渣鼻组的阳性反应率高于对照组，但差异无统计学意义。此外，酒渣鼻组对变应原的阳性反应总数高于对照组，分别为26例和17例。
结论
接触性超敏反应可能与酒渣鼻并存。其识别具有重要的临床意义，影响长期管理，并证明对酒渣鼻患者进行斑贴试验的合理性。
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