Norman D J, Barry J M, Wetzsteon P J
Transplantation. 1985 Mar;39(3):253-5. doi: 10.1097/00007890-198503000-00007.
Six patients who underwent a prospective blood transfusion protocol developed antibodies reactive with 41-95% of a lymphocyte panel. These antibodies disappeared 9-18 months later, and all six patients were successfully transplanted with cadaver kidneys in spite of positive crossmatches with donor T and B cells using their most reactive noncurrent sera. Crossmatches with their current sera were negative. No patient underwent plasmapheresis, blood transfusions, or immunosuppression between the time of maximum panel reactivity and transplantation. Graft survival was 100% after a mean of 22.3 months, and the mean serum creatinine level was 2.1 mg/dl one year after grafting. A positive anti-donor T or warm B cell crossmatch with the most reactive serum may be disregarded if the most recent serum is crossmatch-negative with a cadaver kidney transplant donor.
六名接受前瞻性输血方案的患者产生了与41%-95%淋巴细胞组反应的抗体。这些抗体在9-18个月后消失，尽管使用其反应最强的非当前血清与供体T细胞和B细胞交叉配型呈阳性，但所有六名患者均成功接受了尸体肾移植。与他们当前血清的交叉配型为阴性。在淋巴细胞组反应最强到移植期间，没有患者接受血浆置换、输血或免疫抑制。平均22.3个月后移植物存活率为100%，移植一年后平均血清肌酐水平为2.1mg/dl。如果最新血清与尸体肾移植供体交叉配型为阴性，那么与反应最强血清的阳性抗供体T细胞或温B细胞交叉配型可能被忽略。
