von Willebrand E, Zola H, Häyry P
Transplantation. 1985 Mar;39(3):258-62.
It has been demonstrated previously that thrombocytes have a role in renal allograft rejection. The purpose of the present studies was to use fine-needle aspiration biopsy techniques during the early postoperative period to determine whether the specific localization of thrombocytes was correlated with the ultimate outcome of renal transplantation. The thrombocyte morphology and location were evaluated using monoclonal antithrombocyte antibody techniques. The results show that loose aggregates, often in combination with granulocytes, are nearly invariably seen in acute blast-cell-dominated reversible rejections; these aggregates disappear from the graft when the inflammation is overcome. In irreversible rejections in which inflammation continues and increases in intensity, the early loose aggregates are followed and accompanied by aggregation of thrombocytes on the graft vascular endothelial cells. The result suggests that thrombocyte aggregation into the graft is a two-stage phenomenon, and that only thrombocyte-graft endothelial cell aggregates are an adverse prognostic sign indicating an unfavorable course of rejection.
先前已证明血小板在肾移植排斥反应中起作用。本研究的目的是在术后早期使用细针穿刺活检技术，以确定血小板的特定定位是否与肾移植的最终结果相关。使用单克隆抗血小板抗体技术评估血小板的形态和位置。结果显示，在以原始细胞为主的急性可逆性排斥反应中，通常可见松散的聚集体，常与粒细胞并存；当炎症消退时，这些聚集体从移植物中消失。在炎症持续且强度增加的不可逆性排斥反应中，早期的松散聚集体之后并伴有血小板在移植血管内皮细胞上的聚集。结果表明，血小板向移植物内的聚集是一个两阶段现象，并且只有血小板 - 移植物内皮细胞聚集体是提示排斥反应进程不利的不良预后标志。
