Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou 225000, Jiangsu, China.
Cell Mol Biol (Noisy-le-grand). 2024 Jun 5;70(6):92-96. doi: 10.14715/cmb/2024.70.6.15.
The currest study aimed to measure the effects of laparoscopic radical gastrectomy on inflammatory response along with immune function in gastric cancer (GC) patients. Seventy patients with GC in our hospital were retrospectively chosen to be the study objects and separated into control group (CG, 35 cases) and observation group (OG, 35 cases). Patients in the OG received radical laparotomy. Patients in the OG received laparoscopic radical gastrectomy. The surgical indicators, postoperative recovery indicators, inflammatory factors, immune function, incidence of adverse reactions along with quality of life of patients in both groups were compared. In contrast to the CG, the operation time of the OG presented as shorter (P<0.05), and the amount of intraoperative blood loss together with postoperative VAS score in the OG presented lower (P<0.05), but the number of lymph nodes dissection presented not statistically significant between 2 groups (P>0.05). The postoperative exhaust time, feeding time as well as hospital stay in the OG presented shorter relative to the CG (P<0.05). The serum levels of CRP, and IL-6 together with TNF-α presented elevated in both groups after surgery, and those in the OG presented lower when compared with the CG (P<0.05). The serum levels of IgA, and IgG together with IgM presented declined in both groups after surgery, and those in the OG presented higher when compared with the CG (P<0.05). The incidence of postoperative complications in the OG presented reduction relative to the CG (P<0.05). The GLQI scores of the OG presented significantly higher relative to the CG at discharge (P<0.05). Compared with radical gastrectomy, laparoscopic radical gastrectomy is more suitable for the treatment of GC, which can reduce the inflammatory response and promote the immune function of GC patients.
本研究旨在测量腹腔镜根治性胃切除术对胃癌（GC）患者炎症反应和免疫功能的影响。选择我院 70 例 GC 患者作为研究对象，分为对照组（CG，35 例）和观察组（OG，35 例）。OG 组患者接受根治性剖腹手术。OG 组患者接受腹腔镜根治性胃切除术。比较两组患者的手术指标、术后恢复指标、炎症因子、免疫功能、不良反应发生率及生活质量。与 CG 相比，OG 组的手术时间更短（P<0.05），术中出血量和术后 VAS 评分更低（P<0.05），但两组淋巴结清扫数量无统计学差异（P>0.05）。OG 组术后排气时间、进食时间和住院时间均短于 CG 组（P<0.05）。两组术后 CRP、IL-6 和 TNF-α 血清水平均升高，OG 组低于 CG 组（P<0.05）。两组术后 IgA、IgG 和 IgM 血清水平均下降，OG 组高于 CG 组（P<0.05）。OG 组术后并发症发生率低于 CG 组（P<0.05）。OG 组出院时 GLQI 评分明显高于 CG 组（P<0.05）。与根治性胃切除术相比，腹腔镜根治性胃切除术更适合治疗 GC，可减轻 GC 患者的炎症反应，促进免疫功能。
