School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Translational Chinese Medicine Key Laboratory of Sichuan Province, State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Sichuan Engineering Technology Research Center of Genuine Regional Drug, Sichuan Provincial Engineering Research Center of Formation Principle and Quality Evaluation of Genuine Medicinal Materials, Sichuan Institute for Translational Chinese Medicine, Sichuan Academy of Chinese Medicine Sciences, Chengdu, China.
Food Funct. 2024 Jul 1;15(13):6798-6824. doi: 10.1039/d3fo05739a.
In recent decades, natural compounds derived from herbal medicine or dietary sources have played important roles in prevention and treatment of various diseases and have attracted more and more attention. Curcumin, extracted from the and widely used as food spice and coloring agent, has been proven to possess high pharmacological value. However, the pharmacological application of curcumin is limited due to its poor systemic bioavailability. As a major active metabolite of curcumin, tetrahydrocurcumin (THC) has higher bioavailability and stability than curcumin. Increasing evidence confirmed that THC had a wide range of biological activities and significant treatment effects on diseases. In this paper, we reviewed the research progress on the biological activities and therapeutic potential of THC on different diseases such as neurological disorders, metabolic syndromes, cancers, and inflammatory diseases. The extensive pharmacological effects of THC involve the modulation of various signaling transduction pathways including MAPK, JAK/STAT, NF-κB, Nrf2, PI3K/Akt/mTOR, AMPK, Wnt/β-catenin. In addition, the pharmacokinetics, drug combination and toxicology of THC were discussed, thus providing scientific basis for the safe application of THC and the development of its dietary supplements and drugs.
近几十年来，源自草药或膳食来源的天然化合物在预防和治疗各种疾病方面发挥了重要作用，引起了越来越多的关注。姜黄素是从 中提取的，广泛用作食品香料和着色剂，已被证明具有很高的药理学价值。然而，由于其较差的全身生物利用度，姜黄素的药理学应用受到限制。四氢姜黄素（THC）作为姜黄素的主要活性代谢物，其生物利用度和稳定性均高于姜黄素。越来越多的证据证实，THC 具有广泛的生物学活性，对神经退行性疾病、代谢综合征、癌症和炎症性疾病等疾病具有显著的治疗效果。本文综述了 THC 在不同疾病中的生物学活性和治疗潜力的研究进展，如神经退行性疾病、代谢综合征、癌症和炎症性疾病。THC 的广泛药理作用涉及多种信号转导途径的调节，包括 MAPK、JAK/STAT、NF-κB、Nrf2、PI3K/Akt/mTOR、AMPK、Wnt/β-catenin。此外，还讨论了 THC 的药代动力学、药物联合和毒理学，从而为 THC 的安全应用以及其膳食补充剂和药物的开发提供了科学依据。
