Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing, China.
College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
J Sci Food Agric. 2024 Oct;104(13):7928-7938. doi: 10.1002/jsfa.13624. Epub 2024 Jun 5.
Maslinic acid (MA), a pentacyclic triterpene acid, is widely distributed in natural plants and mainly found in the fruit and leaves of olives and hawthorn. MA has been reported as having many health-promoting functions, such as anticancer, anti-inflammation and neuroprotective activities. According to previous study, hawthorn extract has certain hepatoprotective effects. However, the detailed mechanism is still unclear, especially the effect of MA on gut microbiota.
Our study reveals that MA effectively counteracts alcohol-induced liver injury and oxidative stress. It mitigates alcohol-induced intestinal barrier damage, reverses increased permeability and reduces translocation of lipopolysaccharide (LPS). This prevents LPS/Toll-like receptor 4 activation, leading to decreased TNF-α and IL-1β production. Furthermore, MA rebalances gut microbiota by reversing harmful bacterial abundance and enhancing beneficial bacteria post-alcohol consumption.
MA, through modulation of gut microbiota, alleviates alcohol-induced liver injury via the gut-liver axis. These findings support the potential use of MA as a functional food ingredient for preventing or treating alcoholic liver disease. © 2024 Society of Chemical Industry.
马林酸（MA）是一种五环三萜酸，广泛分布于天然植物中，主要存在于橄榄和山楂的果实和叶子中。MA 具有许多促进健康的功能，如抗癌、抗炎和神经保护活性。根据先前的研究，山楂提取物具有一定的保肝作用。然而，其详细机制仍不清楚，特别是 MA 对肠道微生物群的影响。
我们的研究表明，MA 能有效对抗酒精引起的肝损伤和氧化应激。它减轻了酒精引起的肠道屏障损伤，逆转了通透性增加，并减少了脂多糖（LPS）的易位。这防止了 LPS/Toll 样受体 4 的激活，从而减少了 TNF-α 和 IL-1β 的产生。此外，MA 通过逆转有害细菌丰度和增强有益细菌来重新平衡肠道微生物群，从而减轻酒精引起的肝损伤。
MA 通过调节肠道微生物群，通过肠道-肝脏轴缓解酒精引起的肝损伤。这些发现支持将 MA 用作预防或治疗酒精性肝病的功能性食品成分的潜力。 © 2024 化学工业协会。
