莫西多明对慢性心力衰竭患者静息及运动时血流动力学的影响。

The influence of molsidomine on the hemodynamics of patients with chronic heart failure at rest and during exercise.

作者信息

Larbig D T, Milstrey H R, Nasse H, Kahle T

出版信息

Am Heart J. 1985 Mar;109(3 Pt 2):688-90. doi: 10.1016/0002-8703(85)90683-0.

Abstract

The effect of molsidomine on hemodynamic properties was studied in 10 patients with chronic congestive heart failure in New York Heart Association functional classes III and IV. Ten patients with the same degree of heart failure served as control subjects. All patients were receiving standard therapy with digitalis and diuretics. Administration of a single dose of 4 mg of molsidomine orally in the initial phase resulted in significant decreases of pulmonary artery pressure, pulmonary capillary pressure, and right atrial pressure at rest and during exercise (p less than 0.01 and p less than 0.01, respectively). After long-term oral treatment with 4 mg of molsidomine three times daily over a period of 3 weeks, single dose administration of 4 mg of molsidomine orally again caused significant decreases of pulmonary artery, pulmonary capillary, and right atrial pressure at rest and during exercise (range p less than 0.01 to p less than 0.02). Cardiac output, heart rate, systemic arterial pressure, pulmonary artery resistance, and systemic arterial resistance were essentially unchanged.

摘要

在10例纽约心脏协会心功能分级为III级和IV级的慢性充血性心力衰竭患者中研究了吗多明对血流动力学特性的影响。另外10例心力衰竭程度相同的患者作为对照。所有患者均接受洋地黄和利尿剂的标准治疗。在初始阶段口服单剂量4毫克吗多明，导致静息和运动时肺动脉压、肺毛细血管压和右心房压显著降低（分别为p<0.01和p<0.01）。在3周的时间里，每天口服3次4毫克吗多明进行长期治疗后，再次口服单剂量4毫克吗多明，导致静息和运动时肺动脉、肺毛细血管和右心房压显著降低（范围为p<0.01至p<0.02）。心输出量、心率、体动脉压、肺血管阻力和体动脉阻力基本未改变。