Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Medical Research Center for Geriatric Diseases (Xiangya Hospital), Central South University, Changsha, Hunan, China.
Eur J Pain. 2024 Oct;28(9):1585-1595. doi: 10.1002/ejp.2296. Epub 2024 Jun 4.
Migraine is a common and burdensome neurological disorder. The causal relationship between sedentary behaviours (SBs) and migraine remains instinct. We aimed to evaluate the roles of SBs including watching TV, using computer and driving in the risk of migraine.
We conducted a univariable and multivariable Mendelian randomization (MR) study based on summary datasets of large genome-wide association studies. The inverse variance weighted method was utilized as the primary analytical tool. Cochran's Q, MR-Egger intercept test, MR pleiotropy residual sum and outlier and leave-one-out were conducted as sensitivity analysis. Additionally, we performed a meta-analysis to combine the causal estimates.
In the discovery analysis, we identified causal associations between time spent watching TV and an increased risk of migraine (p = 0.015) and migraine without aura (MO) (p = 0.002). Such causalities with increasing risk of migraine (p = 0.005), and MO (p = 0.006) were further verified using summary datasets from another study in the replication analysis. There was no significant causal association found between time spent using computer, driving and migraine or its two subtypes. The meta-analysis and multivariable MR analysis also strongly supported the causal relationships between time spent watching TV and an increased risk of migraine (p = 0.0003 and p = 0.034), as well as MO (p < 0.0001 and p = 0.0004), respectively. These findings were robust under all sensitivity analysis.
Our study suggested that time spent watching TV may be causally associated with an increased risk of migraine, particularly MO. Large-scale and well-designed cohort studies may be warranted for further validation.
This study represents the first attempt to investigate whether a causal relationship exists between SBs and migraine. Utilizing MR analysis helps mitigate reverse causation bias and confounding factors commonly encountered in observational cohorts, thereby enhancing the robustness of derived causal associations. Our MR analysis revealed that time spent watching TV may serve as a potential risk factor for migraine, particularly MO.
偏头痛是一种常见且负担沉重的神经疾病。久坐行为（SBs）与偏头痛之间的因果关系仍然不明确。我们旨在评估包括看电视、使用电脑和驾驶在内的 SBs 在偏头痛风险中的作用。
我们基于大型全基因组关联研究的汇总数据集进行了单变量和多变量孟德尔随机化（MR）研究。反方差加权法被用作主要分析工具。进行 Cochran's Q、MR-Egger 截距检验、MR 多效性残差和异常值以及留一法作为敏感性分析。此外，我们进行了荟萃分析以合并因果估计值。
在发现分析中，我们确定了看电视时间与偏头痛（p=0.015）和无先兆偏头痛（MO）（p=0.002）风险增加之间存在因果关系。在复制分析中，使用另一项研究的汇总数据集进一步验证了与偏头痛（p=0.005）和 MO（p=0.006）风险增加的这种因果关系。使用计算机的时间、驾驶与偏头痛或其两种亚型之间没有发现显著的因果关系。荟萃分析和多变量 MR 分析也强烈支持看电视时间与偏头痛（p=0.0003 和 p=0.034）以及 MO（p<0.0001 和 p=0.0004）风险增加之间的因果关系。在所有敏感性分析下，这些发现都是稳健的。
我们的研究表明，看电视时间可能与偏头痛风险增加有关，尤其是 MO。可能需要进行大规模和精心设计的队列研究以进一步验证。
本研究首次尝试调查 SBs 与偏头痛之间是否存在因果关系。利用 MR 分析有助于减轻观察性队列研究中常见的反向因果关系偏倚和混杂因素，从而增强得出的因果关系的稳健性。我们的 MR 分析表明，看电视时间可能是偏头痛的一个潜在危险因素，尤其是 MO。
