Division of Arrhythmia and Electrophysiology, Department of Cardiology, Yuksek Ihtisas Cardiovascular Building, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.
J Cardiovasc Electrophysiol. 2024 Aug;35(8):1579-1588. doi: 10.1111/jce.16336. Epub 2024 Jun 4.
There is a lack of studies in the literature directly investigating the relationship between atrial tachycardia (AT) and left atrial (LA)/left atrial appendage (LAA) thrombus, and current guidelines do not provide strong recommendations regarding the use of transesophageal echocardiography (TEE) before AT catheter ablation. This study aims to elucidate the relationship between AT and the presence of LA/LAA thrombus and contribute to the literature on the use of TEE before AT catheter ablation.
This single-center retrospective observational study screened patients who underwent TEE between February 10, 2019, and February 10, 2023. Patients were assigned to the AT patient and control groups. TEE was conducted to exclude thrombus in the AT ablation group. The control group included patients who underwent TEE for interatrial septum evaluation and had LA imaging during TEE but did not have atrial arrhythmia. To mitigate bias between the AT patient group and the control group, they were randomized 1:1 using propensity-score matching (PSM). Following randomization, each group consisted of 49 patients.
All analyses were conducted after PSM. There were no statistically significant differences between the AT patient and control groups in terms of baseline clinical characteristics and echocardiographic features. Additionally, no significant differences were found between the blood viscosities calculated at low and high shear rates in both groups. The study revealed a significant difference between the two groups in the presence of LA spontaneous echo contrast (SEC) (24.5% in AT group vs 0% in Control group, p = .001), but not in the presence of thrombi (8.2% in AT group vs 0% in Control group, p = .117).
Compared to the control group, the presence of SEC was significantly higher in the AT patient group. The increased frequency of SEC in AT patients suggests the hypothesis that AT may contribute to LA stasis. The routine use of TEE before AT catheter ablation remains controversial, despite the presence of LA thrombus and SEC in the AT patient group. The clinical assessment of thrombus presence before the procedure must be conducted on a patient-specific basis.
目前,文献中缺乏直接研究房性心动过速(AT)与左心房(LA)/左心耳(LAA)血栓之间关系的研究,且当前指南并未就 AT 导管消融术前使用经食管超声心动图(TEE)提供强有力的推荐意见。本研究旨在阐明 AT 与 LA/LAA 血栓之间的关系,并为 AT 导管消融术前使用 TEE 提供文献依据。
这是一项单中心回顾性观察性研究,筛选了 2019 年 2 月 10 日至 2023 年 2 月 10 日期间接受 TEE 的患者。患者被分为 AT 患者组和对照组。在 AT 消融组中进行 TEE 以排除血栓。对照组包括因房间隔评估而接受 TEE 检查且在 TEE 期间进行 LA 成像但无房性心律失常的患者。为了减轻 AT 患者组和对照组之间的偏倚,采用倾向评分匹配(PSM)进行 1:1 随机分组。随机分组后,每组各有 49 例患者。
所有分析均在 PSM 后进行。AT 患者组和对照组在基线临床特征和超声心动图特征方面无统计学差异。此外,两组在高低切变率下计算的血液粘度也无显著差异。研究结果显示,两组间 LA 自发性回声对比(SEC)的存在存在显著差异(AT 组为 24.5%,对照组为 0%,p=0.001),但血栓的存在无显著差异(AT 组为 8.2%,对照组为 0%,p=0.117)。
与对照组相比,AT 患者组 SEC 的存在显著更高。AT 患者中 SEC 发生率增加提示了 AT 可能导致 LA 停滞的假说。尽管 AT 患者组存在 LA 血栓和 SEC,但在 AT 导管消融术前常规使用 TEE 仍存在争议。在术前必须根据患者的具体情况进行血栓存在的临床评估。