Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Maryland Cardiac Services Quality Initiative Inc., Baltimore, Maryland.
J Surg Res. 2024 Aug;300:309-317. doi: 10.1016/j.jss.2024.05.022. Epub 2024 Jun 4.
Prior investigations assessing the impact of race/ethnicity on outcomes after mitral valve (MV) surgery have reported conflicting findings. This analysis aimed to examine the association between race/ethnicity and operative presentation and outcomes of patients undergoing MV and tricuspid valve (TV) surgery.
We retrospectively analyzed 5984 patients (2730 female, median age 63 y) who underwent MV (n = 4,534, 76%), TV (n = 474, 8%) or both MV and TV (n = 976, 16%) surgery in a statewide collaborative from 2012 to 2021. The influence of race/ethnicity on preoperative characteristics, MV and TV repair rates, and postoperative outcomes was assessed for White (n = 4,244, 71%), Black (n = 1,271, 21%), Hispanic (n = 144, 2%), Asian (n = 171, 3%), and mixed/other race (n = 154, 3%) patients.
Black patients, compared to White patients, had higher Society of Thoracic Surgeons predicted risk of morbidity/mortality (24.5% versus 13.1%; P < 0.001) and more comorbid conditions. Compared to White patients, Black and Hispanic patients were less likely to undergo an elective procedure (White 71%, Black 55%, Hispanic 58%; P < 0.001). Degenerative MV disease was more prevalent in White patients (White 62%, Black 41%, Hispanic 43%, Asian 51%, mixed/other 45%; P < 0.05), while rheumatic disease was more prevalent in non-White patients (Asian 28%, Hispanic 26%, mixed/other 25%, Black 17%, White 10%;P < 0.05). After multivariable adjustment, repair rates and adverse postoperative outcomes, including mortality, did not differ by racial/ethnic group.
Patient race/ethnicity is associated with a higher burden of comorbidities at operative presentation and MV disease etiology. Strategies to improve early detection of valvular heart disease and timely referral for surgery may improve outcomes.
先前评估种族/民族对二尖瓣 (MV) 手术后结局影响的研究报告结果相互矛盾。本分析旨在研究种族/民族与 MV 和三尖瓣 (TV) 手术患者的手术表现和结局之间的关系。
我们回顾性分析了 2012 年至 2021 年期间全州合作机构中 5984 名患者(2730 名女性,中位年龄 63 岁)的资料,其中 4534 名(76%)患者行 MV 手术,474 名(8%)患者行 TV 手术,976 名(16%)患者同时行 MV 和 TV 手术。评估了白种人(n=4244,71%)、黑种人(n=1271,21%)、西班牙裔(n=144,2%)、亚洲人(n=171,3%)和混血/其他种族(n=154,3%)患者的术前特征、MV 和 TV 修复率以及术后结局是否受到种族/民族的影响。
与白种人相比,黑种人患者的胸外科医师协会预测发病率/死亡率更高(24.5%对 13.1%;P<0.001),合并症更多。与白种人相比,黑种人和西班牙裔患者择期手术的可能性更小(白种人 71%,黑种人 55%,西班牙裔 58%;P<0.001)。退行性 MV 疾病在白种人患者中更为常见(白种人 62%,黑种人 41%,西班牙裔 43%,亚洲人 51%,混血/其他种族 45%;P<0.05),而风湿性疾病在非白种人患者中更为常见(亚洲人 28%,西班牙裔 26%,混血/其他种族 25%,黑种人 17%,白种人 10%;P<0.05)。多变量调整后,不同种族/民族组的修复率和不良术后结局(包括死亡率)无差异。
患者种族/民族与较高的手术时合并症负担和 MV 疾病病因有关。改善瓣膜性心脏病早期检测和及时转介手术的策略可能会改善结局。