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种族和民族差异对二尖瓣和三尖瓣手术患者的影响。

Racial and Ethnic Variations in Patients Undergoing Mitral and Tricuspid Valve Surgery.

机构信息

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Maryland Cardiac Services Quality Initiative Inc., Baltimore, Maryland.

出版信息

J Surg Res. 2024 Aug;300:309-317. doi: 10.1016/j.jss.2024.05.022. Epub 2024 Jun 4.

Abstract

INTRODUCTION

Prior investigations assessing the impact of race/ethnicity on outcomes after mitral valve (MV) surgery have reported conflicting findings. This analysis aimed to examine the association between race/ethnicity and operative presentation and outcomes of patients undergoing MV and tricuspid valve (TV) surgery.

METHODS

We retrospectively analyzed 5984 patients (2730 female, median age 63 y) who underwent MV (n = 4,534, 76%), TV (n = 474, 8%) or both MV and TV (n = 976, 16%) surgery in a statewide collaborative from 2012 to 2021. The influence of race/ethnicity on preoperative characteristics, MV and TV repair rates, and postoperative outcomes was assessed for White (n = 4,244, 71%), Black (n = 1,271, 21%), Hispanic (n = 144, 2%), Asian (n = 171, 3%), and mixed/other race (n = 154, 3%) patients.

RESULTS

Black patients, compared to White patients, had higher Society of Thoracic Surgeons predicted risk of morbidity/mortality (24.5% versus 13.1%; P < 0.001) and more comorbid conditions. Compared to White patients, Black and Hispanic patients were less likely to undergo an elective procedure (White 71%, Black 55%, Hispanic 58%; P < 0.001). Degenerative MV disease was more prevalent in White patients (White 62%, Black 41%, Hispanic 43%, Asian 51%, mixed/other 45%; P < 0.05), while rheumatic disease was more prevalent in non-White patients (Asian 28%, Hispanic 26%, mixed/other 25%, Black 17%, White 10%;P < 0.05). After multivariable adjustment, repair rates and adverse postoperative outcomes, including mortality, did not differ by racial/ethnic group.

CONCLUSIONS

Patient race/ethnicity is associated with a higher burden of comorbidities at operative presentation and MV disease etiology. Strategies to improve early detection of valvular heart disease and timely referral for surgery may improve outcomes.

摘要

简介

先前评估种族/民族对二尖瓣 (MV) 手术后结局影响的研究报告结果相互矛盾。本分析旨在研究种族/民族与 MV 和三尖瓣 (TV) 手术患者的手术表现和结局之间的关系。

方法

我们回顾性分析了 2012 年至 2021 年期间全州合作机构中 5984 名患者(2730 名女性,中位年龄 63 岁)的资料,其中 4534 名(76%)患者行 MV 手术,474 名(8%)患者行 TV 手术,976 名(16%)患者同时行 MV 和 TV 手术。评估了白种人(n=4244,71%)、黑种人(n=1271,21%)、西班牙裔(n=144,2%)、亚洲人(n=171,3%)和混血/其他种族(n=154,3%)患者的术前特征、MV 和 TV 修复率以及术后结局是否受到种族/民族的影响。

结果

与白种人相比,黑种人患者的胸外科医师协会预测发病率/死亡率更高(24.5%对 13.1%;P<0.001),合并症更多。与白种人相比,黑种人和西班牙裔患者择期手术的可能性更小(白种人 71%,黑种人 55%,西班牙裔 58%;P<0.001)。退行性 MV 疾病在白种人患者中更为常见(白种人 62%,黑种人 41%,西班牙裔 43%,亚洲人 51%,混血/其他种族 45%;P<0.05),而风湿性疾病在非白种人患者中更为常见(亚洲人 28%,西班牙裔 26%,混血/其他种族 25%,黑种人 17%,白种人 10%;P<0.05)。多变量调整后,不同种族/民族组的修复率和不良术后结局(包括死亡率)无差异。

结论

患者种族/民族与较高的手术时合并症负担和 MV 疾病病因有关。改善瓣膜性心脏病早期检测和及时转介手术的策略可能会改善结局。

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