Beijing Hui-Long-Guan Hospital, Peking University, Beijing, 100096, China; Xinjiang Key Laboratory of Neurological Disorder Research, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830063, China.
Clinical Nutrition Department, Friendship Hospital, Urumqi, 830049, China.
J Psychiatr Res. 2024 Aug;176:33-39. doi: 10.1016/j.jpsychires.2024.05.048. Epub 2024 May 30.
Sleeping late has been associated with cognitive impairment, and insufficient sleep can affect the secretion of feeding-related cytokines. Feeding-related cytokines may contribute to cognitive deficits resulting from delayed bedtime. Glial cell line-derived neurotrophic factor (GDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF), which are feeding-related neurotrophic factors, have been associated with improved cognitive function and neuroprotective abilities. Enhanced expression of GDNF and MANF is linked to increased energy expenditure and hyperphagia, respectively.
This study aimed to investigate the association between cerebrospinal fluid (CSF) GDNF, MANF, cognition, and sleep time and to explore the moderating effects of GDNF and MANF on cognitive impairment in individuals who sleep late.
This cross-sectional study included participants (mean age 31.76 ± 10.22 years) who were categorized as ≤23 o'clock sleepers (n = 66) and >23 o'clock sleepers (n = 125) based on sleep time. Cognition was assessed using Montreal Cognitive Assessment (MoCA), and GDNF and MANF levels in CSF were measured.
MANF may play a moderating role in the relationship between sleep time and cognition (R = 0.06, β = 0.59, p = 0.031). Age showed a negative correlation with MoCA scores (R = 0.08, β = -0.18), while education exhibited a positive correlation (β = 0.17, both p < 0.05). Only ≤23 o'clock sleepers exhibited a negative correlation between MANF levels and BMI (r = -0.35, p = 0.005).
This study provides hitherto undocumented evidence of the potential protective effect of CSF MANF on cognitive impairment of late sleepers, which suggests that maintaining a regular sleep schedule may contribute to cognition and overall health, with MANF playing a role in this process.
晚睡与认知障碍有关，睡眠不足会影响与进食相关的细胞因子的分泌。与进食相关的细胞因子可能导致由于晚睡导致的认知缺陷。胶质细胞源性神经营养因子（GDNF）和中脑星形胶质细胞源性神经营养因子（MANF）是与进食相关的神经营养因子，它们与认知功能的提高和神经保护能力有关。GDNF 和 MANF 的表达增强分别与能量消耗增加和摄食增加有关。
本研究旨在探讨脑脊液（CSF）GDNF、MANF、认知与睡眠时间之间的关系，并探讨 GDNF 和 MANF 对晚睡者认知障碍的调节作用。
本横断面研究纳入了根据睡眠时间分为≤23 点睡眠者（n=66）和>23 点睡眠者（n=125）的参与者（平均年龄 31.76±10.22 岁）。使用蒙特利尔认知评估（MoCA）评估认知，测量 CSF 中的 GDNF 和 MANF 水平。
MANF 可能在睡眠时间与认知之间的关系中起调节作用（R=0.06，β=0.59，p=0.031）。年龄与 MoCA 评分呈负相关（R=0.08，β=-0.18），而教育程度呈正相关（β=0.17，均 p<0.05）。只有≤23 点睡眠者的 MANF 水平与 BMI 呈负相关（r=-0.35，p=0.005）。
本研究提供了迄今为止尚未记录的脑脊液 MANF 对晚睡者认知障碍的潜在保护作用的证据，这表明保持规律的睡眠时间可能有助于认知和整体健康，而 MANF 在这个过程中发挥作用。
