Greenham L W, Peacock D B
Ann Neurol. 1985 Feb;17(2):206-9. doi: 10.1002/ana.410170219.
Mice inoculated intracerebrally before the age of 5 days with homogenates of autopsied brain tissue from patients with Creutzfeldt-Jakob (C-J), Alzheimer's, or Pick's diseases showed highly significant decreases in life span when compared with sham-inoculated control mice. With C-J disease there was strong indication of horizontal transmission of the agent to uninoculated mice caged with the inoculated mice. While the results with C-J disease were not unexpected in view of the known infectious etiology of the disease, the results obtained with Alzheimer's and Pick's diseases suggest that previously undetermined infectious or toxic agents may be associated with these two diseases, which currently have unresolved etiologies. Mice inoculated with autopsied brain tissue from patients with multiple sclerosis or subacute sclerosing panencephalitis had life spans similar to those of the control mice.
5日龄前经脑内接种来自克雅氏（C-J）病、阿尔茨海默病或皮克病患者尸检脑组织匀浆的小鼠，与假接种对照小鼠相比，其寿命显著缩短。对于C-J病，有强有力的迹象表明病原体可横向传播给与接种小鼠同笼饲养的未接种小鼠。鉴于该疾病已知的感染性病因，C-J病的结果并不意外，但阿尔茨海默病和皮克病的结果表明，以前未确定的感染性或毒性因子可能与这两种目前病因尚未明确的疾病有关。接种来自多发性硬化症或亚急性硬化性全脑炎患者尸检脑组织的小鼠，其寿命与对照小鼠相似。
