Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland.
The Radiotherapy Department, University Clinical Center of the Medical University of Silesia, Katowice, Poland.
Int J Radiat Oncol Biol Phys. 2024 Nov 15;120(4):1076-1083. doi: 10.1016/j.ijrobp.2024.05.027. Epub 2024 Jun 4.
Acute radiation dermatitis (ARD) is the most common side effect reported by patients undergoing radiation therapy (RT). Currently, the assessment of the severity of the reaction is based on the visual assessment of the skin, which is a subjective method, depending on many factors. The main aim of this study was to investigate the usefulness of hyperspectral imaging (HSI) in the assessment of ARD and find physiological factors that could be correlated with ARD.
In this clinical pilot trial, weekly acquisitions of hyperspectral camera images of irradiated skin were performed for 5 weeks of RT and at the posttreatment follow-up visit which took place 30 to 40 days after the last fraction of RT. At the same time, the severity of radiodermatitis was assessed based on the criteria of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE). The content and concentration of chromophores in irradiated skin were quantitatively determined using a hyperspectral camera.
The use of HSI supported by image analysis and processing methods allowed for the determination of the content and distribution of hemoglobin and melanin in the irradiated skin. It was found that the hemoglobin concentration is correlated with the subjective assessment made according to the CTCAE protocol.
HSI is a sensitive and specific method of analyzing the concentration of chromophores in the skin, including hemoglobin. A clear correlation was found between hemoglobin concentration and CTCAE v.5 scale because of which HSI can be considered as an objective method of skin assessment during RT.
急性放射性皮炎（ARD）是接受放射治疗（RT）的患者报告的最常见的副作用。目前，反应严重程度的评估基于皮肤的视觉评估，这是一种主观方法，取决于许多因素。本研究的主要目的是探讨高光谱成像（HSI）在评估 ARD 中的有用性，并找到可能与 ARD 相关的生理因素。
在这项临床试点研究中，每周对接受 RT 的 5 周内的辐照皮肤进行高光谱相机图像采集，并在 RT 最后一次分割后 30 至 40 天进行治疗后随访时进行。同时，根据国立癌症研究所不良事件通用术语标准（CTCAE）的标准评估放射性皮炎的严重程度。使用高光谱相机定量测定辐照皮肤中色团的含量和浓度。
使用 HSI 并结合图像分析和处理方法，能够确定辐照皮肤中血红蛋白和黑色素的含量和分布。结果发现，血红蛋白浓度与根据 CTCAE 方案进行的主观评估相关。
HSI 是一种分析皮肤中包括血红蛋白在内的色团浓度的敏感和特异方法。血红蛋白浓度与 CTCAE v.5 量表之间存在明显相关性，因此 HSI 可以被认为是 RT 期间皮肤评估的客观方法。
