Williams R C, Kilpatrick K
Arch Intern Med. 1985 Feb;145(2):297-300.
Mitral and aortic valves removed at emergency cardiac surgery from a patient with infective endocarditis caused by Streptococcus viridans were studied by immunofluorescence to ascertain the extent and pattern of various immune reactants within the large valvular vegetations. Heavy intravalvular deposits of IgG as well as bacterial antigen were present. Much more focal interstitial IgM and C3 deposits were noted within vegetations and valve substance. Diffuse endocardial and subendocardial deposition of C5b-C9 and C9 complement neoantigens was present. Direct staining of valvular tissues and vegetations for rheumatoid factor showed extensive interstitial tissue deposition. These findings emphasize the large amounts of immune reactants and constituents of immune complexes present in valves and vegetations of patients with infective endocarditis.
对一名因草绿色链球菌引起感染性心内膜炎而在急诊心脏手术中切除的二尖瓣和主动脉瓣进行了免疫荧光研究，以确定大的瓣膜赘生物内各种免疫反应物的范围和模式。瓣膜内存在大量IgG以及细菌抗原沉积。在赘生物和瓣膜组织内发现了更多局灶性的间质IgM和C3沉积。存在C5b - C9和C9补体新抗原的弥漫性心内膜和心内膜下沉积。对瓣膜组织和赘生物进行类风湿因子直接染色显示间质组织广泛沉积。这些发现强调了感染性心内膜炎患者瓣膜和赘生物中存在大量免疫反应物和免疫复合物成分。
