Raphael M, Pouletty P, Cavaille-Coll M, Rozenbaum W, Homond A, Nonnenmacher L, Delcourt A, Gluckman J C, Debre P
Arch Pathol Lab Med. 1985 Feb;109(2):128-32.
Lymph node biopsies of 12 patients at high risk for acquired immunodeficiency syndrome (AIDS) with generalized lymphadenopathy (AIDS-related complex [ARC]) and seven controls with conventional lymph node hyperplasia were examined by light microscopy and immunohistochemical staining of frozen tissue. The immunohistochemical results were quantified by planimetric means. Our findings show that the T helper/T suppressor-cytotoxic (Th/Tsc) ratio in lymph nodes from ARC patients is significantly decreased with respect to controls and that this decrease precedes the change in the Th/Tsc ratio in peripheral blood. Our findings distinguish between lymphadenopathy from patients with ARC and other forms of hyperplasia; the relation to AIDS is discussed.
对12例获得性免疫缺陷综合征（AIDS）高危且有全身淋巴结病（艾滋病相关综合征[ARC]）患者的淋巴结活检组织以及7例患有传统淋巴结增生的对照者的组织进行了冷冻组织的光镜检查和免疫组化染色。通过平面测量法对免疫组化结果进行定量分析。我们的研究结果表明，ARC患者淋巴结中的辅助性T细胞/抑制性-细胞毒性T细胞（Th/Tsc）比值相对于对照组显著降低，且这种降低先于外周血中Th/Tsc比值的变化。我们的研究结果区分了ARC患者的淋巴结病与其他形式的增生；并讨论了其与艾滋病的关系。
