Husson A, Bouazza M, Buquet C, Vaillant R
Biochem J. 1985 Jan 1;225(1):271-4. doi: 10.1042/bj2250271.
The activity changes of the urea-cycle enzymes were monitored in cultured foetal hepatocytes after dexamethasone and insulin treatments. Addition of dexamethasone induced the development of carbamoyl-phosphate synthetase, argininosuccinate synthetase, argininosuccinase and arginase activities as soon as day 16.5 of gestation. When insulin was added together with dexamethasone, it markedly inhibited the steroid-induced increase in carbamoyl-phosphate synthetase, argininosuccinate synthetase and argininosuccinase activities.
在地塞米松和胰岛素处理后，对培养的胎儿肝细胞中尿素循环酶的活性变化进行了监测。从妊娠第16.5天起，添加地塞米松就诱导了氨甲酰磷酸合成酶、精氨琥珀酸合成酶、精氨琥珀酸酶和精氨酸酶活性的发展。当胰岛素与地塞米松一起添加时，它显著抑制了类固醇诱导的氨甲酰磷酸合成酶、精氨琥珀酸合成酶和精氨琥珀酸酶活性的增加。
