地塞米松和胰岛素对培养的大鼠胎儿肝细胞中五种尿素循环酶发育的作用。
Role of dexamethasone and insulin on the development of the five urea-cycle enzymes in cultured rat foetal hepatocytes.
作者信息
Husson A, Bouazza M, Buquet C, Vaillant R
出版信息
Biochem J. 1985 Jan 1;225(1):271-4. doi: 10.1042/bj2250271.
Abstract
The activity changes of the urea-cycle enzymes were monitored in cultured foetal hepatocytes after dexamethasone and insulin treatments. Addition of dexamethasone induced the development of carbamoyl-phosphate synthetase, argininosuccinate synthetase, argininosuccinase and arginase activities as soon as day 16.5 of gestation. When insulin was added together with dexamethasone, it markedly inhibited the steroid-induced increase in carbamoyl-phosphate synthetase, argininosuccinate synthetase and argininosuccinase activities.
摘要
在地塞米松和胰岛素处理后，对培养的胎儿肝细胞中尿素循环酶的活性变化进行了监测。从妊娠第16.5天起，添加地塞米松就诱导了氨甲酰磷酸合成酶、精氨琥珀酸合成酶、精氨琥珀酸酶和精氨酸酶活性的发展。当胰岛素与地塞米松一起添加时，它显著抑制了类固醇诱导的氨甲酰磷酸合成酶、精氨琥珀酸合成酶和精氨琥珀酸酶活性的增加。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver.禁食和无蛋白饮食对大鼠肝脏尿素循环酶水平的不同影响。
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Recent Prog Horm Res. 1961;17:539-68.
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