Department of Anatomy, Quaid-e-Azam Medical College, Bahawalpur, Pakistan.
Department of Anatomy, Army Medical College/National University of Medical Sciences, Rawalpindi, Pakistan.
J Coll Physicians Surg Pak. 2024 Jun;34(6):641-645. doi: 10.29271/jcpsp.2024.06.641.
To determine the preventive effect of coenzyme Q10 (CoQ10) on the testicular histology of rats exposed chronically to mosquito coil smoke.
Experimental study. Place and Duration of the Study: Department of Anatomy, Army Medical College/National University of Medical Sciences, Rawalpindi, Pakistan, from January to December 2020.
Thirty male Sprague Dawley rats were divided into three groups of 10 rats each. Group A was the healthy control. Group B rats were exposed to allethrin-based mosquito coil smoke for 12 weeks (4 hours/day). Group C rats received coenzyme Q10 (CoQ10, 10mg/kg/day) through oral gavage, in addition to 12 weeks of mosquito coil smoke exposure (4 hours/day). At the end of the study, testicular histology was compared among three groups including the germinal epithelium height, seminiferous tubule diameter, and testicular capsule thickness, while adjusting for the body weight variations among rats.
The rats in Group B, exposed only to mosquito coil smoke showed testicular disruption, characterised by dilated seminiferous tubules (p <0.001), reduced germinal epithelial height (p <0.001), and thickened testicular capsule (p <0.007), as compared to the control group rats. However, the germinal epithelium height (p = 0.73) and testicular capsule thickness (p = 0.31) of rats receiving CoQ10 in addition to mosquito coil smoke inhalation were not significantly different from the control group.
Prolonged inhalation of allethrin-based mosquito coil smoke can cause testicular disruption among rats. The oral CoQ10 administration can effectively prevent the histomorphological adverse effects on the testis among rats exposed to mosquito coil smoke.
Allethrin, Coenzyme Q10, Germinal epithelium, Mosquito coil, Seminiferous tubules, Testicular capsule.
确定辅酶 Q10（CoQ10）对长期暴露于蚊香烟雾的大鼠睾丸组织学的预防作用。
实验研究。
巴基斯坦拉瓦尔品第陆军医科大学/国立医科大学解剖学系，2020 年 1 月至 12 月。
将 30 只雄性 Sprague Dawley 大鼠分为 3 组，每组 10 只。A 组为健康对照组。B 组大鼠每天暴露于含丙烯菊酯的蚊香烟雾中 12 周（4 小时/天）。C 组大鼠除了每天暴露于蚊香烟雾（4 小时/天）12 周外，还通过口服给予辅酶 Q10（CoQ10，10mg/kg/天）。研究结束时，比较三组大鼠的睾丸组织学，包括生精上皮高度、精曲小管直径和睾丸囊厚度，并调整大鼠体重变化。
仅暴露于蚊香烟雾的 B 组大鼠的睾丸受到破坏，表现为精曲小管扩张（p<0.001）、生精上皮高度降低（p<0.001）和睾丸囊增厚（p<0.007），与对照组大鼠相比。然而，接受 CoQ10 加蚊香烟雾吸入的大鼠的生精上皮高度（p=0.73）和睾丸囊厚度（p=0.31）与对照组大鼠无显著差异。
长期吸入丙烯菊酯基蚊香烟雾可导致大鼠睾丸受损。口服 CoQ10 可有效预防大鼠暴露于蚊香烟雾时对睾丸的组织形态学不良影响。
丙烯菊酯、辅酶 Q10、生精上皮、蚊香、精曲小管、睾丸囊。
