Char D H, Phillips T L
Br J Ophthalmol. 1985 Mar;69(3):177-9. doi: 10.1136/bjo.69.3.177.
The relative efficacy of various types of treatment in preventing metastatic uveal melanoma is unclear. We have performed a phase I-II non-randomised trial to determine if patients with large (greater than 15 mm in diameter or greater than 5 mm in thickness) uveal melanomas would benefit from pre-enucleation irradiation. Twenty-eight patients were treated between 1978 and 1983 by means of 5 X 5 cm anterior wedge pair ports on a 4 me V linear accelerator. Each patient received five 4 gray (400 rad) fractions over a five-day period for a total of 20 Gy. Enucleation was performed by a single surgeon within five days after treatment. The mean follow-up of the patients was 24 months (range 7-54 months). All melanomas were histologically confirmed. Four patients (14%) have developed metastatic tumour with a mean interval between diagnosis and death of 25 months. No significant perioperative or long-term morbidity was observed.
各种治疗方法在预防转移性葡萄膜黑色素瘤方面的相对疗效尚不清楚。我们进行了一项I-II期非随机试验，以确定患有大尺寸（直径大于15毫米或厚度大于5毫米）葡萄膜黑色素瘤的患者是否能从眼球摘除术前放疗中获益。1978年至1983年间，28例患者在4兆电子伏直线加速器上通过5×5厘米前楔形对野进行治疗。每位患者在五天内接受五个4戈瑞（400拉德）分次照射，总量为20戈瑞。治疗后五天内由一名外科医生进行眼球摘除术。患者的平均随访时间为24个月（范围7 - 54个月）。所有黑色素瘤均经组织学证实。4例患者（14%）发生了转移性肿瘤，诊断至死亡的平均间隔时间为25个月。未观察到明显的围手术期或长期发病率。
