Ebrahimnejad Pedram, Heydarabadi Paria Fadaee, Amiri Fereshteh Talebpour, Mirzaee Fatemeh, Ahmadi Melika, Shahani Somayeh
Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Curr Drug Deliv. 2025;22(3):358-371. doi: 10.2174/0115672018282735240528072715.
The regeneration of tissue damage involves a series of molecular and cellular events that can be mediated by various natural compounds. Recent studies have highlighted the anti-inflammatory, anti-ulcer, and skin-protecting properties of Cydonia oblonga (Quince), which are mainly attributed to phenolic compounds. These compounds may have some drawbacks when targeting wound applications, including low bioavailability at the wound site. Moreover, to overcome these limitations, surfactant-based nanovesicular systems have been developed as carriers of such compounds for wound healing.
This study aimed to highlight the possible therapeutic potential of niosome-based hydrogel from Quince extract to stabilize and deliver the related bioactive compounds to full-thickness wounds in rats.
The niosomal hydrogel was prepared using a thin-film hydration method with the fruit extract (70% methanol). The formulation was optimized by evaluating size, zeta potential, dispersion index, and drug encapsulation efficiency. Full-thickness wounds were created on the dorsal cervical area of Wistar rats, and histopathological analysis of biopsy specimens was conducted on the 12th day of treatment.
Under the study conditions, niosomal hydrogel displayed good physicochemical stability. Histopathological findings demonstrated that niosomal gel promoted angiogenesis, fibroblast maturation, collagen deposition, keratinization, and epidermal layer formation more effectively than control and hydrogel base. Furthermore, niosomal gel treatment markedly reduced inflammation. The total phenol concentration was determined to be 13.34 ± 0.90 mg gallic acid equivalents per gram of dried extract.
The niosomal hydrogel containing C. oblonga extract shows potential as a novel approach for wound healing, warranting further investigation in this field.
组织损伤的修复涉及一系列分子和细胞事件，这些事件可由多种天然化合物介导。最近的研究突出了榅桲（Cydonia oblonga）的抗炎、抗溃疡和皮肤保护特性，这些特性主要归因于酚类化合物。这些化合物在用于伤口治疗时可能存在一些缺点，包括在伤口部位的生物利用度低。此外，为了克服这些局限性，基于表面活性剂的纳米囊泡系统已被开发为这些化合物用于伤口愈合的载体。
本研究旨在突出基于非离子表面活性剂囊泡的榅桲提取物水凝胶在稳定并将相关生物活性化合物递送至大鼠全层伤口方面可能的治疗潜力。
采用薄膜水化法，用果实提取物（70%甲醇）制备非离子表面活性剂囊泡水凝胶。通过评估粒径、zeta电位、分散指数和药物包封效率对制剂进行优化。在Wistar大鼠的颈背部区域制造全层伤口，并在治疗的第12天对活检标本进行组织病理学分析。
在研究条件下，非离子表面活性剂囊泡水凝胶表现出良好的物理化学稳定性。组织病理学结果表明，与对照组和水凝胶基质相比，非离子表面活性剂囊泡凝胶更有效地促进血管生成、成纤维细胞成熟、胶原蛋白沉积、角化和表皮层形成。此外，非离子表面活性剂囊泡凝胶治疗显著减轻了炎症。测定每克干燥提取物中总酚浓度为13.34±0.90毫克没食子酸当量。
含有榅桲提取物的非离子表面活性剂囊泡水凝胶显示出作为一种新型伤口愈合方法的潜力，值得在该领域进一步研究。
