脊柱手术中25-羟基维生素D水平与手术部位感染的关系
Relationship between 25-hydroxy Vitamin D level and surgical site infection in spine surgery.
作者信息
Liu Serena, Sulovari Aron, Joo Peter, Thirukumaran Caroline, Benn Lancelot, Mesfin Addisu
机构信息
Department of Orthopaedic Surgery, University of Rochester Medical Center, Rochester, New York, United States.
Department of Anesthesiology, Westchester Medical Center, Valhalla, New York, United States.
出版信息
Surg Neurol Int. 2024 May 24;15:173. doi: 10.25259/SNI_135_2024. eCollection 2024.
BACKGROUND
25-hydroxy Vitamin D (25[OH]D) level has been shown to have antimicrobial and wound healing effects in animal models. Low preoperative 25(OH)D has been shown to correlate with surgical site infection (SSI) in thoracolumbar spine surgery.
METHODS
This study involved 545 patients undergoing thoracolumbar spine surgery from 2012 to 2019 at an academic medical center. We evaluated the serum 25(OH)D level (i.e., adequate level = level 30-60 ng/dL), along with SSI, body mass index, and smoking status. Statistical analysis was done using bivariate analysis with Fisher's exact, Wilcoxon rank-sum test and multivarible logisitic regression analyses.
RESULTS
We included 545 patients in the study, and there were no statistical differences in the average preoperative 25(OH)D between SSI and non-SSI groups. The average 25(OH)D in the non-SSI group was 31.6 ng/dL ± 13.6, and the SSI group was 35.7 ng/dL ± 20.2 ( = 0.63).
CONCLUSION
SSI rates following thoracolumbar spine surgery were not affected by preoperative 25(OH)D levels.
背景
在动物模型中，25-羟基维生素D（25[OH]D）水平已显示出具有抗菌和促进伤口愈合的作用。术前低25（OH）D水平已被证明与胸腰椎手术的手术部位感染（SSI）相关。
方法
本研究纳入了2012年至2019年在一家学术医疗中心接受胸腰椎手术的545例患者。我们评估了血清25（OH）D水平（即，充足水平=30-60 ng/dL），以及SSI、体重指数和吸烟状况。使用Fisher精确检验、Wilcoxon秩和检验的双变量分析和多变量逻辑回归分析进行统计分析。
结果
我们在研究中纳入了545例患者，SSI组和非SSI组术前平均25（OH）D水平无统计学差异。非SSI组的平均25（OH）D为31.6 ng/dL±13.6，SSI组为35.7 ng/dL±20.2（P=0.63）。
结论
胸腰椎手术后的SSI发生率不受术前25（OH）D水平的影响。
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